San Francisco Bay Clinical Trials Unit

描述(申请人提供)：旧金山湾区经历了特别严重的艾滋病毒流行，男男性行为者(MSM)、黑人和拉丁裔人口在该地区受到的影响最大。苏珊·布赫宾德博士和黛安·哈夫利尔博士分别是艾滋病毒预防和治疗的科学领导者。他们将共同组成旧金山湾区临床试验单位(SFBay CTU)，隶属于HVTN、HPTN、MTN和ACTG。这个综合研究组织将通过这些网络实现三个具体目标：1)通过科学领导促进预防和治疗科学及其交叉；2)有效地实施临床试验，并出色地遵守协议，同时 让不同的社区参与进来；以及3)培养艾滋病毒预防和治疗科学领域的新一代不同的领导人。Buchbinder博士和Havlir博士还有一批才华横溢的研究人员，他们在整个网络中提供领导，在许多科学领导委员会和工作组任职，并主持一系列预防和治疗方案。3个临床研究网站(Buchbinder领导的Bridge HIV、Havlir领导的加州大学旧金山分校和Zolopa领导的斯坦福大学)在登记、保留和遵守方案要求方面都有出色的记录，并积极让当地社区参与他们的研究。 相关性：新成立的旧金山湾临床试验单位将在旧金山、奥克兰、圣何塞及其周边社区进行艾滋病毒疫苗、预防和治疗试验。通过将旧金山湾区的领先科学家和不同的社区聚集在一起，这个新的研究单位将开发预防和治疗艾滋病毒感染的方法，并致力于有效的艾滋病毒疫苗和治疗。

DESCRIPTION (provided by applicant): The San Francisco Bay Area has experienced a particularly intense HIV epidemic, with men who have sex with men (MSM), Black, and Latino populations most heavily impacted in the region. Drs. Susan Buchbinder and Diane Havlir are scientific leaders in HIV prevention and treatment, respectively. Together they will form the San Francisco Bay Area Clinical Trials Unit (SFBay CTU), affiliated with the HVTN, HPTN, MTN, and ACTG. This integrated research organization will accomplish 3 specific aims through these Networks: 1) advance prevention and treatment science and their intersection through scientific leadership; 2) implement clinical trials efficiently and with excellent adherence to protocol while engaging diverse communities; and 3) develop a new generation of diverse leaders in HIV prevention and treatment science. Drs. Buchbinder and Havlir are joined by a diverse pool of talented investigators who have provided leadership across the Networks, serving on numerous scientific leadership committees and working groups and chairing a range of prevention and treatment protocols. The 3 Clinical Research Sites (Bridge HIV led by Buchbinder, UCSF led by Havlir, and Stanford led by Zolopa) all have a record of excellence in enrollment, retention, and adherence to protocol requirements, and actively engage local communities in their research. RELEVANCE: The newly formed San Francisco Bay Clinical Trials Unit will conduct HIV vaccine, prevention and treatment trials in San Francisco, Oakland, San Jose, and their surrounding communities. By bringing together leading scientists and a diverse community in the San Francisco Bay Area, this new research unit will develop ways to prevent and treat HIV infections and work towards an effective HIV vaccine and cure.