Integrative Imaging Core (IIC)

观察、测量和记录生物样品或生物体行为特征的能力是科学研究的核心。综合成像核心（IIC）的总体目标是提供熟练和知识渊博的工作人员，将最先进的成像技术应用于KIDDRC研究计划。 HC是系统进化的产物，致力于满足KIDDRC研究人员的成像需求。 最初成立于1978年，作为组织学核心，它在1990年发展和扩展到包括图像分析，1997年随着数字成像的出现而增强，并在2002年纳入微阵列功能。核心在2007年经历了一次转型，当时它搬到了Hemenway生命科学创新中心（HLSIC）专门为HC设计的空间，并获得了超过300万美元的主要设备。的HC 随着与Hoglund脑成像中心（HBIC）建立正式合作伙伴关系，该公司将不断发展。 HC将各种资源整合到一个软件包中，其共同点是它们都基于整合或支持成像技术的方法（毕竟，微阵列扫描仪只不过是一个花哨的共聚焦显微镜）。我们试图将这些技术整合为一个连续体;从分子到细胞再到整个生物体，许多KIDDRC项目都包含了这一连续体的全部或一部分。的 人力资源的纵向整合通过提供集中化和一站式采购，促进了这些技术的获取和协调，并鼓励私人部门采用多学科方法来研究问题。

The ability to view, measure and record characteristics of biological samples or an organism's behavior lies at the heart of scientific investigation. The overall objective ofthe Integrative Imaging Core (IIC) is to provide skilled and knowledgeable staff to apply state-of-the-art imaging-based technologies to KIDDRC research programs. HC is the product of systematic evolution devoted to meeting the imaging needs of KIDDRC investigators. Originally established in 1978 as a histology core, it evolved and expanded to incorporate image analysis in 1990, was enhanced with the advent of digital imaging in 1997, and incorporated microarray capabilifies in 2002. The core underwent a transformation in 2007 when it moved to space designed specifically for the HC in the Hemenway Life Sciences Innovation Center (HLSIC) and received over $3M for major equipment. The HC confinues to evolve with the establishment of a formal partnership with the Hoglund Brain Imaging Center (HBIC). HC incorporates into one package a variety of resources with the common thread that they are all based on approaches that incorporate or support imaging technologies (a microarray scanner is, after all, little more than a fancy confocal microscope). We have attempted to integrate these technologies as a continuum; from molecule to cell to whole organism, and many KIDDRC programs embrace all or a part of this confinuum. The vertical integration of HC facilitates access and coordination of these technologies by providing centralization and one-stop shopping, and encourages Pls to adopt multidisciplinary approaches to research problems.