New England Regional Coordinating Center for the NINDS Stroke Trials Network

描述(由申请人提供)：我们建议创建新英格兰地区协调中心(NERCC)，这是一个由波士顿和马萨诸塞州西部的医院和EMS机构组成的综合团队，将作为NINDS卒中试验网络的顶级登记地点和充满活力的贡献者。我们的团队包括大波士顿地区的许多主要成人学术中风中心，我们的30家医院新英格兰TeleStroke转介网络将进一步扩大我们的潜在招聘范围。所有核心医院在临床试验的成功管理和绩效方面都有经过证明的记录。具体地说，所有医院都有成熟的研究基础设施，通过跨学科的强有力的合作，执行正在进行的中风神经学临床研究。首席研究员Lee H.Schwamm医学博士和合作调查员在管理成功的转化性临床研究计划、指导委员会成员和各自领域的国家领导职位方面带来了一套互补的技能。我们的团队包括经验丰富的临床研究人员，包括血管神经学、急诊医学、神经血管内科学、神经外科、神经重症监护、神经成像、中风康复以及成人和儿童的临床前基础和翻译中风调查。NERCC团队的优势包括1)多名调查人员之间密切的个人和专业联系；2)来自不同医院的大量患者 3)在多中心试验中拥有科学成就、创新和受试者招募记录的优秀现场研究人员团队；4)NINDS资助的现有研究和临床试验管理基础设施；5)现有的临床研究项目，例如波士顿大学和哈佛大学的神经病学临床研究所、NIH临床和翻译科学奖项目；急性卒中的翻译研究专业项目(SPOTRIAS)和神经病学紧急治疗试验以及NeuroNEXT临床协调中心。此外，还将利用与波士顿和伍斯特医院前服务的整合来支持NERCC的目标。总体而言，NERCC团队拥有开发新的翻译科学并成功执行NINDS卒中试验网络阶段1、2和3研究的资源、远见和热情。

DESCRIPTION (provided by applicant): We propose to create the New England Regional Coordinating Center (NERCC), an integrated team of hospitals and EMS agencies in Boston and Western Massachusetts that will serve as a top-enrolling site and vibrant contributor to the NINDS Stroke Trials Network. Our group includes many of the major adult academic stroke centers in the Greater Boston area, and our 30 hospital New England TeleStroke referral network will extend our potential recruitment even further. All core hospitals have a proven track record of successful management and performance of clinical trials. In particular, all hospitals have an established research infrastructure that performs ongoing clinical research in stroke neurology with strong collaborations across disciplines. Principal investigator Lee H. Schwamm, MD, and Co-Investigators bring a complementary set of skills in managing successful translational clinical research programs, membership on Steering Committees, and positions of national leadership in their fields. Our team includes seasoned clinical investigators in vascular neurology, emergency medicine, neuroendovascular, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and preclinical basic and translational stroke investigation i both adults and children. Strengths of the NERCC team include 1) close personal and professional ties between multiple investigators; 2) large patient population from diverse hospital settings in a major metropolitan area; 3) talented teams of site investigators with track records o scientific achievement, innovation, and subject recruitment in multicenter trials; 4) robust existing NINDS-funded research and clinical trial management infrastructure; 5) existing clinical research programs, e.g., Neurology Clinical Research Institute, NIH Clinical and Translational Science Award programs at Boston University and across Harvard; Sites in the Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) and Neurology Emergency Treatment Trials and NeuroNEXT Clinical Coordinating Center. In addition, integration with Boston and Worcester prehospital services will be leveraged to support the goals of the NERCC. Overall, the NERCC Team has the resources, vision, and enthusiasm to develop new translational science and successfully execute the NINDS Stroke Trials Network Phase 1, 2 and 3 studies.