Request for Nikon N-SIM/N-STORM Super Resolution Microscope

 描述（由申请人提供）： 摘要光学显微镜在生物医学研究中的重要作用，近年来由于突破了光衍射的物理限制而得到了很大的发展。尼康N-SIM/N-STORM超分辨率显微镜可以实现高达20 nm的分辨率。这种能力将使弗吉尼亚州西部纽约医疗保健系统（VAWNYHS）的研究人员能够推动新发现的界限，否则这是不可能的。整个纽约西部地区都没有这样的系统。在VAWNYHS的研究将极大地受益于超分辨率显微镜。显微镜将帮助VA研究人员可视化，表征和了解不同的亚细胞区室，如线粒体，树突棘，微管，丝状伪足等，在各种疾病条件下如何工作，以及治疗药物如何纠正疾病。它对于研究微生物的内部结构也非常有用。对于VA的使命来说，许多病原体的体积很小，这使得这些物种非常难以研究和控制。因此，研究治疗剂对各种微生物内部结构的影响的能力对于发现治疗和控制感染的新方法非常关键。这种革命性工具的可用性 将率先在VAWNYHS为退伍军人及其家属的利益许多创新的发现。

 DESCRIPTION (provided by applicant): Abstract Light microscope, which is so essential to biomedical research, has been significantly improved by recent advances to break the physical limitation imposed by light diffraction. The Nikon N-SIM/N-STORM Super Resolution Microscope can achieve resolution up to 20 nm. This ability will enable researchers at VA Western New York Healthcare System (VAWNYHS) to push the boundaries of new discoveries that would otherwise be impossible. There is no such a system in the entire Western New York area. Research at VAWNYHS will tremendously benefit from a Super Resolution Microscope. The microscope will help VA researchers to visualize, characterize and understand how different subcellular compartments such as mitochondria, dendritic spines, microtubules, filopodia, etc, work under various disease conditions and how therapeutic agents may correct the diseased conditions. It is also extremely useful for the study of internal structures of microbes. The small size of many pathogens important for VA's mission makes these species extremely hard to study and control. The ability to study the effect of therapeutic agents on the internal structure of various microbes is thus very critical to the discovery of new ways to treat and control infection. The availability of such a revolutionary tool will spearhead many innovative discoveries at VAWNYHS for the benefits of veterans and their families.