Cooperative Multicenter Reproductive Medicine Network UNC Clinical Site

描述（由申请人提供）：REI的北卡罗来纳大学（UNC）分部很高兴提交这份提案，成为生殖医学网络（RMN）的成员。北卡罗来纳大学在成功的跨部门患者护理协调和创新的跨学科研究方面有着悠久的历史。妇产科有正在进行的科研项目31个，其中r01项目3个，u型奖项目3个，合同和分包合同多个，其中临床试验18个。北卡罗来纳大学生殖医学研究中心的研究人员在生殖医学的多个领域进行研究，包括临床试验、转化、临床和流行病学研究。我们在研究工作中有着强大的合作传统，在招聘和保留研究课题方面有着良好的记录。该司的临床实践，UNC生育，提供连续的护理从

DESCRIPTION (provided by applicant): The University of North Carolina (UNC) Division of REI is pleased to submit this proposal to become a member of the Reproductive Medicine Network (RMN). UNC has a history of successful interdepartmental patient care coordination and innovative inter- and transdisciplinary research. The Department of Obstetrics and Gynecology has 31 ongoing research projects that include 3 R01s, 3 U-type awards, and multiple contracts and subcontracts, including 18 clinical trials. UNC RMN investigators conduct research in multiple areas of reproductive medicine in a portfolio that includes clinical trials an translational, clinical, and epidemiological research. We have a strong tradition of working collaboratively in our research endeavors and a solid track record of recruitment and retention of research subjects. The Division's clinical practice, UNC Fertility, offers a continuum of care from in-depth evaluation to comprehensive treatment of patients experiencing problems of infertility and other diseases/disorders affecting reproduction. Our patient population is racially and ethnically diverse. We have assembled a Senior Advisory Team whose members have mastered the intricacies of capitated research funding and have expertise in randomized clinical trial design and implementation. These individuals will be available to provide guidance and input into operating a site as part of a large national network, provide intellectual support in th design of clinical trials that the UNC site may choose to propose, and assist with the implementation of network protocols as needed. The current divisional research support team includes 2 full-time study coordinators, 1 full-time lab manager, and 1 full-time and 2 part-time research assistants. Fiscal oversight will be provided by the Center for Women's Health Research. Our concept proposal is a randomized controlled trial designed to test the hypothesis that male antioxidant therapy will improve sperm motility and reduce DNA fragmentation leading to higher fertilization and lower miscarriage rates in couples trying to conceive naturally. This proposal addresses goals of the RMN by focusing on two areas of high interest to the NICHD: 1) evaluation of therapies to improve sperm quality and natural conception and 2) evaluation of the effect of nutritional supplementation on male fertility.