Vector Biology Research and Integrated Vector Management For Malaria Control

在拉丁美洲非亚马逊地区成功控制和最终消除疟疾需要有效控制作为疟疾媒介的按蚊。ICEMR网络的每个国家，哥伦比亚、危地马拉、巴拿马和秘鲁，都有一个以病媒控制为特色的国家疟疾控制规划。然而，由于作为疟疾媒介的按蚊种类信息不足、人为环境变化对疟原虫传播动态影响的不确定性、媒介控制的有效工具有限以及NMCPs的综合媒介管理（IVM）组件不完全开发，其有效性受到限制。

Successful malaria control and eventual elimination in the non-Amazonian region of Latin America requires effective control of Anopheles mosquitoes that serve as malaria vectors. Each country of this ICEMR network, Colombia, Guatemala, Panama, and Peru, has a National Malaria Control Program (NMCP) that features vector control. However, effectiveness is limited by insufficient information on species of Anopheles mosquitoes that serve as malaria vectors, uncertainties regarding the impact of anthropogenic environmental changes on the dynamics of malaria parasite transmission, limited effective tools for vector control, and incompletely developed integrated vector management (IVM) components of NMCPs. The goal of this project is to address major gaps in our understanding of the ecology, behavior, vector potential, and control of Anopheles malaria vectors to guide the development and implementation of more effective IVM strategies of NMCPs. Based on extensive preliminary data and experience of team members representing academic institutions and NMCPs in each country within this ICEMR network, priorities for research focus on key scientific questions that have a direct bearing on the future success of vector control operations. This project includes 3 specific aims: 1) investigate the ecology, behavior, and malaria parasite transmission potential of malaria vector species to identify key factors that would facilitate more effective targeted vector control, 2) determine how known and suspected malaria vector species from each country in the ICEMR network differ in their innate vector competence for Plasmodium falciparum and P. vivax, and 3) assess the efficacy of current vector control operations of NMCPs and conduct multi-country field trials of new vector control products that may strengthen capacities of NMCPs to implement effective IVM strategies for vector control, In partnership with NMCPs, the ICEMR team will demonstrate the translational value of research outcomes for improving vector control in ecologically diverse areas o f t he non-Amazonian region through an iterative process of strengthening and evaluating IVM components of NMCPs.