Intellectual and Developmental Disabilities Research Centers 2013

 描述（由申请人提供）：本修订后的申请是为了继续支持肯尼迪克里格研究所和约翰霍普金斯大学的智力和发育障碍研究中心（IDDRC），以响应RFA-HD-14-012。IDDRC将继续支持一个大型，多样化和多学科的研究计划，重点是发展障碍，重点是转化研究，作为世界上首屈一指的教育，临床和生物医学研究机构之一的发展障碍研究的纽带。IDDRC将包括六个核心。行政核心（A）将为中心提供领导，管理和组织支持;协调教育计划的组成部分（讲座和研讨会）;代表中心与研究所和大学管理部门进行互动;并作为NICHD，其他IDDRCs和更广泛社区的同事的界面。临床翻译核心（B）将支持中心研究者开展与受试者招募、IRB相关 活动，生物统计学，并沿着整个翻译途径移动发现。遗传学核心（C）将提供集中的组织培养和细胞遗传学，专门的分子遗传学，微阵列和测序研究，以及生物信息学的援助。转化神经科学核心（D）将提供组织学和临床前成像设施，以及一组高度专业化的检测，靶向与发育障碍相关的代谢物和分子。神经影像学核心（E）将为研究者提供对功能、体积、弥散张量和光谱MR成像数据的采集和定量分析以及采用TMS方法的研究的帮助。最后，行为科学核心（F）将为参与者提供与研究方案合作的培训，神经心理学/认知评估方法的选择，功能磁共振成像激活范例的设计，以及运动功能评估的专门方法。明年将为69个项目提供核心支持，每年的联邦资金超过3400万美元，另外还有一个由该中心直接资助的研究部分。

 DESCRIPTION (provided by applicant): This revised application for continued support of the Intellectual and Developmental Disabilities Research Center (IDDRC) at the Kennedy Krieger Institute and Johns Hopkins University is submitted in response to RFA-HD-14-012. The IDDRC will continue supporting a large, diverse, and multidisciplinary program of research focused on developmental disorders with an emphasis on translational research, serving as the nexus for research focused on developmental disabilities within one of the premiere educational, clinical, and biomedical research institutions in the world. The IDDRC will include six Cores. An Administrative Core (A) will provide leadership, management, and organizational support for the Center; coordinate educational program components (lectures and seminars); represent the Center in interactions with Institute and University administration; and serve as the interface wit colleagues at NICHD, other IDDRCs, and the broader community. A Clinical Translational Core (B) will support Center investigators in activities related to participant recruitment, IRB-related activities, biostatistics, and moving findings along the entire translational pathway. A Genetics Core (C) will provide centralized tissue culture and assistance with cytogenetics, specialized molecular genetics, microarray and sequencing studies, and bioinformatics. A Translational Neuroscience Core (D) will provide histology and preclinical imaging facilities, as well as a group of highly specialized assays that target metabolites and molecules of relevance to developmental disorders. A Neuroimaging Core (E) will provide Investigators with assistance in acquisition and quantitative analysis of data derived from functional, volumetric, diffusion tensor and spectroscopic MR imaging, as well as for studies employing TMS methods. Finally, a Behavior Science Core (F) will offer training of participants for cooperation with research protocols, selection of methods for neuropsychological/cognitive assessment, design of activation paradigms for fMRI, and specialized methods for assessment of motor functioning. Core support this coming year will be provided to 69 projects representing annual federal funding of over $34 million, plus a Research Component funded directly by the Center.