EMA and Lab Assessment of Nicotine Dependence among Dual ENDS Users

描述(由申请者提供)：我的主要职业目标是成为一名专家，利用新颖的实验室、调查和定性方法研究烟草产品特性如何影响烟草使用行为。我参加烟草控制监管研究K01职业发展奖的目的是为了获得培训，研究产品特征，即烟草产品滥用责任和吸引力，如何影响烟草使用行为。为了获得这些知识和必要的研究技能，我建议通过专注于成瘾的行为药理学和人类实验室研究方法的研究，进行指导、教学培训和经验式学习。这项拟议的研究将通过确定CIGA类ECIG和笔状ECIG对ECIG实验和随后的烟草吸烟行为的初始差异影响，为FDA烟草监管做出贡献。据我们所知，这将是第一次将临床实验室和吸烟者ECIG实验的真实数据收集相结合的研究，以及第一次明确比较两种主要ECIG设备类型的效果。结果将直接解决ECIG滥用责任、尼古丁暴露和增强疗效的问题。这项研究还将开始必要的工作，以了解ECIG的可用性对随后的烟草戒烟尝试的影响。这项研究将是我第一次使用人体实验室方法收集初步数据，并应用烟草滥用责任和吸引力对烟草使用行为的影响。此外，这项研究将对我同时进行的关于规范和伤害认知对ECIG实验和燃烧烟草使用的影响的社会和行为研究进行补充和扩展。有了杰出的导师(Ray Niaura博士和Tom Eissenberg博士)，他们致力于我的培训，并相信我提议的研究的重要性，以及施罗德研究所的强有力的机构支持，我准备发展成为一名独立和高效的研究调查员。这一职业发展奖将使我能够将75%的时间用于行为药理学的教学培训，发展临床实验室方法的专业培训，以补充我的调查研究技能，并撰写R01研究建议，以开启我作为烟草监管科学独立调查员的职业生涯。

DESCRIPTION (provided by applicant): My principal career goal is to become an expert in how tobacco product characteristics influence tobacco use behavior using novel laboratory, survey, and qualitative methodologies. My goal for this K01 Career Development Award in Tobacco Control Regulatory Research is to obtain the training to research how product characteristics, namely tobacco product abuse liability and appeal, affect tobacco use behavior. To gain this knowledge and requisite research skills, I propose mentorship, didactic training, and experiential learning through research focused on the behavioral pharmacology of addiction and human laboratory research methods. The proposed research will contribute to FDA tobacco regulation by identifying the initial differential effects of ciga-like and pen-like ECIGs on ECIG experimentation and subsequent tobacco cigarette smoking behavior. To our knowledge, this will be the first study to combine clinical laboratory and real-world data collection of ECIG experimentation in smokers, as well as the first to compare explicitly the effect of the two major ECIG device types. Results will directly address the issues of ECIG abuse liability, nicotine exposure, and reinforcing efficacy. This research will also begin the work necessary to understand the effect of ECIG availability on subsequent tobacco cigarette smoking quit attempts. This study will be my first experience with primary data collection using human lab methods and my application of the effect of tobacco abuse liability and appeal on tobacco use behavior. Additionally, this research will compliment and expand upon my concurrent social and behavioral research on the impact of norms and harm perceptions on ECIG experimentation and combusted tobacco use. With outstanding mentors (Drs. Ray Niaura and Tom Eissenberg) who are committed to my training and believe in the importance of my proposed research, as well as strong institutional support from the Schroeder Institute, I am poised to develop into an independent and highly productive research investigator. This Career Development Award would enable me to devote 75% of my time to didactic training in behavioral pharmacology, develop expertise training in clinical laboratory methods to complement my skills in survey research, and write an R01 research proposals to launch my career as an independent investigator in tobacco regulatory science.