Baylor Intellectual and Developmental Disabilities Research Centers

贝勒医学院智力和发育障碍研究中心（Baylor College of Medicine Intellectual and Developmental Disabilities Research Center，简称CAIDDRC） 成立于1988年8月1日，并在7月1日的最后一次更新中持续获得资金， 2009.该中心致力于推进智力和发育障碍的研究， 解决缺碘症患者及其家庭遇到的问题。具体而言， 残疾人权利委员会将尽可能多地确定智力和发育残疾的原因， 了解介导这些疾病的机制，以预防这些疾病，并提供 干预措施，可以改善受影响的个人的生活质量和改善他们的残疾 只要有可能具体目标是：1）加强在伯明翰的缺碘症研究活动 鼓励和集中研究病因、诊断、预防、发病机制， 2）开发和提供创新和关键的核心技术， 3）促进对缺碘症研究采取多学科办法， 改善中心研究者之间的互动，招募新的研究者进入IDD领域 研究，以及4）促进与研究人员以外的科学和合作互动， 已经证明了对研究和治疗碘缺乏病的重大承诺。该IDDRC的结构围绕 发现IDD的遗传和基因组基础，开发IDD疾病模型， 进行详细的IDD发病机制研究，并开发IDD的新疗法。使命和 通过提供创新的、重要的和成本效益高的服务， 研究核心服务，以支持与使命一致的高质量调查人员和研究项目， 的目的和目标。CNOIDDRC建议A）管理核心，B）临床 翻译核心，C）啮齿动物神经行为核心，D）神经可视化核心，包括 神经病理学、共聚焦和原位RNA，以及（E）神经连接核心，其包括病毒 生产、光遗传学和体内生理学。此外，该委员会将支持一项创新的 临床前研究项目，名为“迈向父亲的基因激活疗法，为安格尔曼 这将为神经发育障碍开发新的、基于基因的治疗方法。这些 核心资源将支持45名研究人员和56个NIH资助的研究项目。在过去的25年里， IDDRC在促进发现IDD的原因方面取得了显著的成功， IDD的病理生理学，以及IDD的治疗方法。持续的资金将使该中心能够 继续支持和扩大这些努力。

The Baylor College of Medicine Intellectual and Developmental Disabilities Research Center (BCM IDDRC) was established August 1, 1988 and has been continuously funded with the last renewal of funding July 1, 2009. The BCM IDDRC is committed to advancing research in intellectual and developmental disabilities to address the problems encountered by individuals with IDD and their families. Specifically, the mission of the BCM IDDRC are to identify as many causes of intellectual and developmental disability as possible, to understand the mechanisms mediating these disorders, to prevent these disorders, and to provide interventions that can improve the quality of life of affected individuals and ameliorate their disability whenever possible. The specific objectives are: 1) To enhance IDD research activities at BCM by encouraging and focusing research efforts on etiology, diagnosis, prevention, mechanism of pathogenesis, and the development of therapies to treat IDD, 2) To develop and provide innovative and critical core facilities to enhance IDD research at BCM, 3) To promote a multidisciplinary approach to IDD research by improving interactions between Center investigators and recruiting new investigators into the field of IDD research, and 4) To promote scientific and collaborative interactions with investigators outside BCM who have demonstrated a major commitment to study and treat IDD. The BCM IDDRC is structured around the major themes of discovering the genetic and genomic basis of IDD, developing disease models of IDD, performing detailed pathogenesis studies of IDD, and developing novel therapies for IDD. The mission and goals of the BCM IDDRC will be accomplished by providing innovative, important, and cost-effective research core services to support high quality investigators and research projects aligned with the mission, goals, and objectives of the IDDRC. The BCM IDDRC proposes A) an Administrative Core, B) a Clinical Translational Core, C) a Rodent Neurobehavioral Core, D) a Neurovisualization Core which includes Neuropathology, Confocal, and RNA in situ, and (E) a Neuroconnectivity Core which includes Viral Production, Optogenetics, and In vivo Physiology. Additionally, the BCM IDDRC will support an innovative preclinical research project entitled "Steps towards a paternal gene activation therapy for Angelman syndrome" that will develop novel, genetically based treatments for that neurodevelopmental disorder. These core resources will support 45 investigators and 56 NIH funded research projects. Over the last 25 years the BCM IDDRC has been remarkably successful in fostering the discovery of the causes of IDD, determining the pathophysiology of IDD, and developing treatments for IDD. Ongoing funding will allow the Center to continue to support and expand these efforts at BCM.