Administrative Core

行政核心

• 批准号: 10451593
• 负责人: David Loren Nelson
• 金额: $ 14.11万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-25 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10451593
• 关键词: Address; Basic Science; Beavers; CGG repeat; Committee Members; Communication; Communities; Development; Discipline of obstetrics; Disease; Ensure; FMR1; FMR1 Premutation; FMR1 repeat; Fostering; Fragile X Premutation; Fragile X Syndrome; Functional disorder; General Population; Generations; Genetic; Goals; Hares; Institution; Journals; Leadership; Literature; Medicine; Michigan; Molecular Genetics; Neurology; Neurosciences; Participant; Pediatrics; Publishing; Recording of previous events; Research; Research Activity; Research Personnel; Research Training; Resources; Role; Schedule; Scientist; Structure; Talents; Therapeutic; Time; Training; Tremor/Ataxia Syndrome; United States National Institutes of Health; Universities; Work; college; interest; medical schools; meetings; member; novel; novel therapeutics; operation; pre-clinical; primary ovarian insufficiency; success; symposium

As described in the Overall component of this proposal, the overarching goal of the proposed Center is to understand and address the molecular and genetic mechanisms underlying the FMR1 premutation disorders, focusing on Fragile X tremor ataxia syndrome (FXTAS) and Fragile X associated primary ovarian insufficiency (FXPOI), and to answer fundamental questions regarding the roles of the CGG repeats in FMR1 function and dysfunction. The proposed Center integrates the substantial talents of research groups at Baylor College of Medicine (BCM), University of Michigan School of Medicine (UM) and Emory University School of Medicine (Emory). These groups have a significant history of collaborative interaction, and their common interests will lead to robust findings that will suggest therapeutic approaches to FXTAS, FXPOI and possibly fragile X syndrome (FXS). A well-defined leadership and management plan overseeing all research endeavors is critical for the success of the proposed work and will ensure that goals set by the Center Investigators are met in a timely and efficient manner. To accomplish the goals of our Center, the Administrative Core will support the Center's Investigators. Led by co-Directors Drs. David Nelson and Peter Todd (leaders of Projects 2 and 1, respectively), and assisted by Ms. LaTonya Beavers, the Administrative Core will be responsible for the management and administration of the overall Center. The planning and coordination of the synergistic research activities will be integrated through this central hub. Efforts will be conducted by an Executive Team, including Drs. Emily Allen and Stephanie Sherman, Project 3 Co-PIs, with the guidance of an Executive Advisory Board, composed of four external committee members who will address all Center operations and help to ensure the timely completion of each proposed project. In addition, the Administrative Core will be responsible for fiscal and resource management, as well as maintaining open lines of communication between Center Investigators, Project Staff, NIH officials, and FX researchers. A significant emphasis will also be placed on communication and engagement with the broader community of scientists and clinicians in neuroscience, genetics, neurology, obstetrics and pediatrics, and with the public. Training and educational opportunities are provided through regularly scheduled journal clubs, research presentations, and an annual Fragile X-Associated Disorders (FXaDs) Symposium beginning in year 2. These activities will foster a deeper interest in FX research in the new generation of young scientists, as well as encourage and stimulate investigators at all levels who may not be in our field to pursue studies related to FXaDs. We envision that the BCM-Michigan-Emory Fragile Research X Center will be a nexus of exciting scientific research, training and preclinical endeavors focused on development of novel therapeutics for FXaDs.

如本提案的总体部分所述，拟建中心的总体目标是： 理解和解决FMR 1前突变的分子和遗传机制 脆性X震颤共济失调综合征（FXTAS）和脆性X相关的原发性 卵巢功能不全（FXPOI），并回答有关CGG作用的基本问题， FMR 1功能和功能障碍的重复。拟建的中心整合了大量的研究人才， 贝勒医学院（Baylor College of Medicine）、密歇根大学医学院（University of Michigan School of Medicine）和埃默里大学（Emory） 埃默里大学医学院。这些团体有着重要的合作互动历史， 他们的共同兴趣将导致强有力的发现，将建议治疗方法，FXTAS，FXPOI 脆性X综合征（FXS）一个明确的领导和管理计划，监督所有研究 努力是成功的建议工作，并将确保中心设定的目标是至关重要的 及时和有效地会见调查人员。为了实现我们中心的目标，行政 核心将支持中心的调查人员。由共同主任大卫纳尔逊和彼得托德博士（ 在LaTonya Beavers女士的协助下，行政核心将 负责整个中心的管理和行政工作。的规划和协调 协同研究活动将通过这一中心枢纽加以整合。将由一名 执行团队，包括艾米丽艾伦和斯蒂芬妮谢尔曼博士，项目3共同PI，在一位 执行咨询委员会，由四名外部委员会成员组成，负责处理中心的所有业务 并协助确保每个拟议项目的及时完成。此外，行政核心将是 负责财政和资源管理，以及保持开放的沟通渠道， 中心研究人员、项目工作人员、NIH官员和FX研究人员。还将重点强调 关于与神经科学领域更广泛的科学家和临床医生社区的沟通和参与， 遗传学、神经学、产科和儿科，以及公众。培训和教育机会 通过定期安排的期刊俱乐部，研究报告和年度脆性X相关 疾病（FXaDs）研讨会从第2年开始。这些活动将培养对外汇研究的更深兴趣 在新一代的年轻科学家，以及鼓励和激励各级研究人员谁可以 不是在我们的领域进行与FXaDs相关的研究。我们设想， 研究X中心将是一个激动人心的科学研究，培训和临床前工作的纽带，重点是 FXaD的新疗法的开发。