Bioinformatics Core

. NGS技术改变了研究的方式。的绝对规模 调查范围已经扩大到可以在一次实验中调查一组个体的整个基因组和转录组。此外，测序可用于在多个调节水平上探测生物现象，包括种系变异、DNA甲基化、mRNA表达和剪接形式丰度、microRNA表达和染色质结构探索。NGS也正在取代其他技术，特别是使用固定内容芯片进行基因分型。NGS正被应用于生物学研究的各个领域，并将成为个体化医学发展的重要工具。没有复杂的生物信息学的序列数据基本上是无用的。拥有一个由经验丰富的生物信息学研究人员和分析师团队组成的技术合作伙伴，与测序操作共处一地，在新墨西哥州是前所未有的。SBC将继续提供网络交钥匙访问发现-使测序和生物信息学。

. NGS technologies have transformed the way in which research is conducted. The sheer scale of inquiry has been expanded to the extent that whole genomes and transcriptomes of cohorts of individuals can be surveyed in a single experiment. Moreover, sequencing can be used to probe biological phenomena at multiple levels of regulation, including germ-line variation, DNA methylation, mRNA expression and splice form abundance, microRNA expression, and chromatin structure exploration. NGS is also displacing other technologies, in particular the use of fixed-content chips for genotyping. NGS is being applied in every field of biological research, and will be an essential tool in the development of individualized medicine. Sequence data without sophisticated bioinformatics is essentially useless. Having a technology partner consisting of an experienced team of bioinformatics researchers and analysts, co-located with the sequencing operation is unprecedented in New Mexico. The SBC will continue to provide the network turn-key access to discovery� enabling sequencing and bioinformatics.