Center for Adaptive Leadership in Symptom Science

描述（由申请人提供）：拟建的卓越中心（P30）将促进生物行为研究，利用适应性领导（AL）框架扩展症状科学，概念化和研究慢性疾病的认知/情感症状。该中心的总体目标是：(1)提高和维持从事跨学科生物行为研究的新护理科学家的生产力，以了解和改善慢性疾病中认知/情感变化的患者的症状，症状窘迫和症状后遗症；(2)通过解决少数群体健康问题，完善现有的或创建新的干预方案和自我报告措施（即患者报告的结果测量信息系统[PROMIS]），协助研究者定制研究方法和干预措施，以优化认知/情感变化人群的研究参与。(3)提高研究者使用纵向定量、定性和混合方法的能力，以检查与认知/情感变化相关的症状、症状后遗症和患者适应的轨迹。中心的工作将分为三个核心：行政核心、指导与奖学金核心、设计与方法核心。该中心的预期成果包括对认知/情感症状和症状后遗症的轨迹进行研究，以描述模式、可变性和随时间的变化，从而获得有关干预时机的关键时期或过渡点所需的知识，确定亚人群（如认知能力水平不同的人群或少数群体的健康需求）内部的差异，并为开发/测试干预措施提供知识，以增强患者的适应能力。

DESCRIPTION (provided by applicant): The proposed Center of Excellence (P30) will promote biobehavioral research to extend symptom science using the Adaptive Leadership (AL) framework to conceptualize and study cognitive/affective symptoms in chronic illness. The overall Center aims are to: (1) Enhance and sustain the productivity of new nursing scientists engaged in interdisciplinary biobehavioral research to understand and ameliorate symptoms, symptom distress, and symptom sequelae using adaptive approaches for people with cognitive/affective changes in chronic illness; (2) Assist investigators to tailor research approaches and interventions to optimize research participation by people with cognitive/affective changes by addressing minority health issues and refining existing, or creating new intervention protocols and self-report measures (i.e., Patient-Reported Outcomes Measurement Information System [PROMIS]. (3) Increase investigator competence in using longitudinal quantitative, qualitative, and mixed method approaches to examine the trajectories of symptoms, symptom sequelae and patient adaptation associated with cognitive/affective changes. The work of the Center will be carried by in three Cores, the Administrative Core, the Mentoring and Scholarship Core, and the Design and Methods Core. Expected outcomes of the center include studies of trajectories of cognitive/affective symptoms and symptom sequelae to describe patterns, variability, and change over time to gain knowledge needed about critical periods or transition points for timing of interventions, identify differences within subpopulatios such as those with varying levels of cognitive ability or minority health needs, and generate knowledge for developing/testing interventions to enhance patients' adaptive capabilities.