Multidisciplinary Fellowship in Dementia Research

 描述(申请人提供)：这是加州大学旧金山分校行为神经学培训计划(BNTP)第二次申请T32资金，由布鲁斯·米勒博士和霍华德·罗森博士共同指导。BNTP于1999年在加州大学旧金山分校的记忆和衰老中心(MAC)内成立，旨在培训行为神经学和神经退行性疾病的临床研究人员。该T32项目成立于2004年，是加州大学旧金山分校唯一一个能够让初级研究人员对神经退行性疾病的临床、流行病学、遗传学和分子特征有全面了解的项目，也是世界上为数不多的提供关于非阿尔茨海默氏症和非遗忘型AD的强化培训的项目之一。该计划的目标是培养从事神经退行性研究的博士后临床研究人员。该计划向完成住院医师资格的MD神经科医生、老年病学家和精神病学家开放。我们计划的一个核心要素是对痴呆症亚型的准确分类和对导致神经退变的特定蛋白质的预测。我们的培训旨在向研究员传授使用临床评估和实验室方法评估和量化导致痴呆的各种蛋白质和其他生物因素的影响的技能。培训时间超过两年。第一年包括我们中心的四个临床项目的研究轮换，包括我们关于额颞部痴呆的项目拨款，我们的阿尔茨海默病研究项目，我们的快速进展性痴呆症项目和我们的临床试验项目。在这一年中，研究员开始发展他们的研究项目与项目导师之一，并发展技能的科学写作，演示，并在数据分析方面使用我们的临床和档案数据。 影像数据库。在第二年，研究员被给予更多的非结构化时间来继续他们的研究项目和计划拨款申请，以支持他们未来的临床研究生涯。这项T32计划直接支持了15名研究员，但通过T32计划开发的基础设施有助于培养更多的博士后研究员。在即将到来的周期中，培训计划将包括改进统计培训和更好地获得统计咨询，加强与加州大学旧金山分校老年病学部的整合，以及更好地利用由加州大学旧金山分校临床翻译科学研究所(CTSI)维护的培训和教师发展资源。随着我们环境的丰富，申请T32的人数和质量都有了戏剧性的增长。因此，在这次续签中，我们要求每年增加三个培训时段，以支持每年三名新研究员，我们将向完成博士和临床认证的神经心理学家开放T32计划。

 DESCRIPTION (provided by applicant): This is the second renewal application requesting T32 funding for the UCSF Behavioral Neurology Training Program (BNTP), co-directed by Drs. Bruce Miller and Howard Rosen. The BNTP was established at UCSF in 1999 within the UCSF Memory and Aging Center (MAC) to train clinical researchers in behavioral neurology and neurodegenerative disease. Founded in 2004, this T32 is the only program at UCSF that allows junior researchers to gain an integrated understanding of the clinical, epidemiological, genetic, and molecular features of neurodegenerative diseases, and is one of the few programs in the world that provides intensive training on the non-Alzheimer's dementias and non-amnestic forms of AD. The goal of the program is to train postdoctoral clinical researchers for a career in neurodegenerative research. The program is open to MD neurologists, geriatricians and psychiatrists who have completed a residency. A core element of our program is accurate classification of dementia subtypes and prediction of the specific proteins causing neurodegeneration. Our training is designed to impart fellows with the skills to evaluate and quantify the effects of various proteins and other biological factors that cause dementia using clinical assessment and laboratory methods. Training takes place over two years. The first year consists of research rotations through four clinical programs at our center including our program project grant on frontotemporal dementia, our Alzheimer's disease research program, our rapidly progressive dementia program and our clinical trials program. During this year, fellows begin development of their research project with one of the program mentors and develop skills in scientific writing, presentation, and in data analysis using archival data from our clinical and imaging databases. In the second year, fellows are given more unstructured time to continue their research project and plan for grant submissions to support their future career in clinical research. Fifteen fellows have been supported directly by this T32, but the infrastructure developed through the T32 program contributes to the education of many additional postdoctoral fellows. In the upcoming cycle the training program will include improved statistical training and better access to statistical consultation, increased integration with the UCSF Division of Geriatrics, and better utilization of the training and faculty development resources maintained by the UCSF Clinical Translational Sciences Institute (CTSI). The quality and number of applicants for this T32 has grown dramatically, as has the richness of our environment. Therefore we have requested three additional training slots per year in this renewal to support three new fellows per year, and we will open the T32 program to neuropsychologists who have completed their PhD and clinical certification.