UTMB Claude D. Pepper Older Americans Independence Center (OAIC)

描述(由申请人提供)：德克萨斯大学医学部(UTMB)克劳德·D·佩珀老年美国人独立中心培养了一种多学科的翻译研究文化，以履行我们的使命，即改善老年人的身体功能和独立性。这一使命的核心是老年研究领域下一代领导者的职业发展和培训。多年来，我们的科学重点已经从对石棺减少机制的特殊兴趣转变为将我们的发现转化为以患者为中心的干预措施，以改善身体功能和独立性。我们在翻译领域的许多领域促进了研究人员之间的科学合作。这些努力促成了下一个周期主题的发展。我们将确定身体功能丧失和获得的途径，并开发有针对性的干预措施，以促进老年人疾病后的功能恢复，并追求以下科学目标：a)确定影响老年人身体功能和疾病后功能恢复的路径；b)确定改善老年患者功能恢复轨迹的潜在干预措施；c)在老年患者的临床试验中确定已确定的干预措施的疗效。方案的具体目标是： 1.通过资助试点和发展项目，促进额外的多学科转化研究的增长，以改善老年人的身体功能和疾病后的功能恢复。 2.培养老年医学研究的未来领导者。 3.招募其他领域的资深调查人员参与与OAIC焦点相关的研究。 4.为资助的老年人功能和康复的翻译研究提供核心支持和增值。 5.促进UTMB调查员与其他OAIC调查员之间的合作。 我们的具体目标将通过协调和整合我们的研究职业发展核心/KL2计划(RCDC/KL2)活动的领导/行政核心(LAC)、试点/探索性研究核心(PESC)和三个资源核心(RC)来实现，这三个资源核心涵盖了我们多学科翻译研究模式的主要领域：临床研究RC1、新陈代谢和生物学RC2以及生物统计和数据管理RC3。

DESCRIPTION (provided by applicant): The University of Texas Medical Branch (UTMB) Claude D. Pepper Older Americans Independence Center has fostered a multidisciplinary translational research culture to fulfill our mission, which is to improve physical function and independence in older adults. Central to this mission is the career development and training of the next generation of leaders in geriatric research. Our scientific focus has evolved over the years from a specific interest in the mechanisms of sarcopenia to the translation of our findings in patient-centered interventions to improve physical function and independence. We have nurtured scientific collaborations among investigators in many areas of the translational spectrum. These efforts have resulted in the development of the theme for the next cycle. We will Identify pathways of physical function loss and gain and develop targeted interventions to improve functional recovery from illness in older adults and pursue the following scientific objectives: a) Identify pathways affecting physical function and functional recovery from illness in older adults; b) Identify potential interventions to improve the trajectories of functional recovery in geriatric patients; c) Determine the efficacy of the identified interventions in clinicl trials in geriatric patients. The programmatic specific aims are: 1. Stimulate the growth of additional multidisciplinary translational research to improve physical function and functional recovery from illness in older adults by funding pilot and developmental projects. 2. Train future leaders in geriatric research. 3. Recruit established investigators in other areas to research related to the OAIC focus. 4. Provide core support and add value to funded translational research on function and recovery in the elderly. 5. Foster collaborations between UTMB investigators and investigators at other OAICs. Our specific aims will be accomplished by supporting multidisciplinary translational teams via coordination and integration through the Leadership/Administrative Core (LAC) of the activities of our Research Career Development Core/KL2 program (RCDC/KL2), the Pilot/Exploratory Studies Core (PESC) and the three Resource Cores (RC) that encompass the major areas of our multidisciplinary translational research model: Clinical Research RC1, Metabolism and Biology RC2, and Biostatistics and Data Management RC3.