Center for Genomic Studies on Mental Disorders

描述（由申请人提供）：NIMH人类遗传学计划（HGI）的目标是进一步了解精神障碍的遗传和环境病因。实现这一目标的主要机制之一是NIMH精神疾病合作基因组学研究中心（“中心”），该中心接收来自NIMH pi的原始生物样本，如血液。该中心将样品加工成DNA、RNA、cDNA或细胞系，然后提交基因组分析。除了生物样本外，该中心还接收每位受试者的临床/表型数据，并最终获得基因组分析结果。经过一段专利期后，临床数据、基因组数据、DNA、RNA、cDNA和细胞系通过一个安全的网站提供给所有nimh批准的研究人员。这种统一处理的生物样本以及来自许多队列的临床和基因组数据的共享利用了NIMH对大量HGI拨款的投资。它通过提供大量适用于调查个体精神障碍遗传基础的数据，提供了关键的研究能力。自1998年10月以来，该中心已提交了147,000份受试者样本，分发了310,000份DNA样本和9,000份细胞系。临床和基因型数据已向约340名研究人员分发了450份，使用这些样本和数据的出版物有260份。从2011年开始，该中心为诱导多能干细胞（iPSC）及其祖体细胞提供细胞系库和鉴定服务。该中心还开发了新的生物信息学和计算基因组学工具和方法，旨在整合和分析大型、独立的基因型和表型数据集，同时解决数据集中的表型和/或基因型差异。中心将不断创新，服务于科研工作者，作为中心的指导方针

DESCRIPTION (provided by applicant): The goal of the NIMH Human Genetics Initiative (HGI) is to further understand the genetic and environmental etiologies of mental disorders. One of the major mechanisms for accomplishing this goal is the NIMH Center for Collaborative Genomics Research on Mental Disorders (the "Center"), which receives raw biosamples such as blood from NIMH PIs. The Center processes samples to DNA, RNA, cDNA or cell lines, which can then be submitted for genomic analyses. Along with biosamples the Center receives clinical/phenotypic data for each subject and, eventually, the results of genomic analyses. After a proprietary period, the clinical data, genomic data, DNA, RNA, cDNA and cell lines are made available to all NIMH-approved researchers through a. secure web site. This sharing of uniformly processed biological samples and clinical and genomic data from many cohorts leverages the NIMH investment in a large number of HGI grants. It provides critical research power by providing a large body of data applicable to investigations on the genetic bases for individual mental disorders. Since October 1998, >147,000 subject samples have been submitted and the Center has distributed >310,000 DNA samples and >9,000 cell lines. There have been >450 distributions of clinical and genotype data to ~340 investigators and >260 publications using these samples and data. Starting in 2011 the Center provided cell line banking and characterization services for induced pluripotent stem cells (iPSC) and their progenitor somatic cells. The Center also develops novel bioinformatics and computational genomics tools and methodologies designed to integrate and analyze large, independent sets of genotypic and phenotypic data while resolving phenotype and/or genotype discrepancies in datasets. As its guiding aim, the Center will continue to innovate in order to serve the scientific needs of NIMH PIs in a flexible and highly accessible manner, while respecting subject confidentiality, informed consent issues and PI prerogatives.