Signals that Control Thymocyte Migration

 描述（由申请人提供）：项目负责人/主要研究者（Robey，Ellen，A）：总结：T细胞协调免疫应答，胸腺中T细胞发育缺陷可导致自身免疫或免疫缺陷。我们已经开发了新的方法来直接可视化和操纵在活胸腺组织中T细胞发育期间TCR信号传导的模式。通过研究这些操作对T细胞发育的影响，我们期望深入了解TCR信号传导，胸腺细胞迁移和不同形式的T细胞选择之间的机制联系。这些信息是开发各种免疫系统相关疾病的改进治疗方法以及提高我们操纵对肿瘤或病原体的免疫反应的能力的关键。OMB编号0925-0001/0002（2012年8月8日至2015年8月31日批准的修订版）2页

 DESCRIPTION (provided by applicant): Program Director/Principal Investigator (Robey, Ellen, A): Summary: T cells orchestrate immune responses, and defects in T cell development in the thymus can lead to auto- immunity or immunodeficiency. We have developed new methods to directly visualize and manipulate the pattern of TCR signaling during T cell development in living thymic tissue. By examining the impact of these manipulations on T cell development, we expect to gain insights into the mechanistic connections between TCR signaling, thymocyte migration, and different forms of T cell selection. Such information is key to developing improved treatments for a variety of immune system related diseases and to improving our ability to manipulate immune response to tumors or pathogens. OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) 2 Page Continuation Format Page