Inflammatory Biomarkers of Diagnosis and Prognosis in Early Stage Lung Cancer

基于我们以前的研究，我们发现肺癌诊断患者中循环细胞因子增加，我们正在检查来自国家肺筛查试验的血浆样本，以获得细胞因子诊断和预后特征。本研究扩展了以前的研究，因为a）这是一项前瞻性研究，B）良性和恶性病变均通过B低剂量螺旋CT检测。我们还在研究来自细胞因子的信号是否在手术后下降并追踪肿瘤复发，作为初步研究，以询问细胞因子是否可用于模拟肿瘤复发。这项研究目前正在进行中。我们还比较了不同的细胞因子检测平台，并确定了最佳和最稳健的生物标志物检测方法。

Building on our previous studies where we found increased circling cytokines among patients with a lung cancer diagnosis, we are examining plasma samples from the National Lung Screening Trial for a cytokine diagnostic and prognostic signature. This study extends previous studies as a) this is a prospective study and b) the lesions both benign and malignant, were detected b low dose helical CT. We are also examining whether the signal from cytokines declines following surgery and tracks with tumor recurrence, as a preliminary study to query whether cytokines could be used to model tumor recurrence. This study is currently ongoing. We are also comparing different cytokine detection platforms and determining the best and most robust method of biomarker detection.