Core B - Clinical

西奈山发展研究中心：核心B(格罗斯曼)|项目总结 临床核心提供认知障碍患者的临床和生物学特征方面的专业知识 丧失和痴呆症以及识别非受损老年人的能力。这些专业知识被用来招募 并保持一批特征良好的参与者，以支持广泛的痴呆症和认知 在MSADRC、西奈山卫生系统(MSHS)和国家倡议内进行的研究 作为国家阿尔茨海默氏症协调中心(NACC)，全基因组阿尔茨海默氏症研究(GWAS)， 阿尔茨海默病合作研究(ADCS)和阿尔茨海默病神经成像计划 (ADNI)。核心的作用是为高标准制定和实施临床程序 老年人的特征跨越正常、前驱症状和受影响对象的不同阶段 变成了做好研究准备的队列。临床核心提供研究对象、组织和数据，以及 与疾病的临床表现、病程、治疗反应、 和招聘可行性，以帮助指导中心内和广泛范围内研究的设计和实施 在MSHS内部。在该中心内，临床核心提供研究的基本要素：受试者和 参与项目1和2的受试者的临床特征； 提供大脑捐赠和其他标本传播到神经病理核心和中心的项目中， 以及地方和国家的研究。核心在评估工具的开发方面进行创新；应用 对新的人群进行评估；使新的成像技术适应临床“真实世界”；以及 新的、研究不足的或用途不同的化合物的临床试验。核心拥有丰富而成功的历史， 对痴呆症研究中代表性不足的群体进行外联，并提供继续开展这项工作的条款 申请。该中心积极培训年轻调查人员，并支持其他领域的调查人员 他们希望研究他们临床人群的认知能力。

Mount Sinai ADRC: Core B (Grossman) | PROJECT SUMMARY The Clinical Core provides expertise in the clinical and biological characterization of individuals with cognitive loss and dementia and the ability to identify non-impaired older individuals. This expertise is utilized to recruit and maintain a cohort of well-characterized participants to support a broad array of dementia and cognitive research conducted within the MSADRC, the Mount Sinai Health System (MSHS,) and national initiatives such as the National Alzheimer's Coordinating Center (NACC), the Genome Wide Alzheimer's Study (GWAS), Alzheimer's Disease Cooperative Studies (ADCS), and the Alzheimer's Disease Neuroimaging Initiative (ADNI). The role of the core is to develop and implement clinical procedures for the high standard characterization of elders spanning the spectrum of normal, prodromal, and various stages of affected subjects into research-ready cohorts. The Clinical Core provides subjects, tissue, and data for studies as well as clinical research expertise related to clinical manifestations of disease, disease course, treatment responses, and recruitment feasibility to help guide the design and implementation of studies within the Center and broadly within the MSHS. Within the Center, the Clinical Core provides the essentials for research: the subjects and their clinical characterization to participate in Projects 1 and 2; the clinical characterization of subjects who provide brain donations and other specimens disseminated to the Neuropathology Core and Center's projects, and local and national research. The Core innovates in the development of assessment tools; application of assessments to new populations; adaptation of new imaging technologies into the clinical `real world'; and clinical trials of novel, under-studied or repurposed compounds. The Core has a rich and successful history of outreach to groups underrepresented in dementia research and provisions to continue this are built into this application. The Core is active in training young investigators and supporting investigators from other fields who wish to study cognition in their clinical populations.