ShEEP Request for UltraFocus DXA

本提案旨在购买Faxitron UltraFocusDXA数字X射线摄影系统， 分辨率双能X射线吸收仪（DEXA）的能力，我们目前的成像能力，提供 关于对骨量、脂肪量、瘦体重和高分辨率平面成像的纵向影响的更好数据， 使用更少的动物和更短的时间-这也将有助于减轻我们拥挤的扫描压力 schedule.对这台设备感兴趣的实验室参与了广泛的资助项目， 研究项目，包括骨代谢、整形外科、癌症生物学、糖尿病和肥胖症。与 UltrafocusDXA系统，我们将能够在最大48 µm和最小6 µm处扫描小鼠， 这将使我们有可能测量我们目前无法测量的骨骼部分。使用 高分辨率平面X射线能力，我们将有能力筛选小鼠的肿瘤，图像骨骼 骨折，甚至评估皮质宽度和骨几何形状。上的床尺寸（摄像机/探测器尺寸） UltrafocusDXA系统比Piximus II系统（目前已过时，但 唯一可用的仪器）并且可以容纳任何大小/重量/年龄的小鼠，甚至大鼠。最后一 鼠标DEXA（月球的Piximus II系统）单元于2005年生产。因为月球停止生产 这些研究单位，技术保障薄弱，维修零部件奇缺。 在我们的VA工厂购买最近推出的Faxitron UltraFocusDXA数字X射线摄影系统 将使我们能够获得可靠的服务和零件，以满足我们的DEXA扫描需求（除了更好的质量， 更快，更灵活的功能）。此外，UltraFocusDXA可用于扫描许多 标本现在正在旧的Piximus II系统上扫描，具有相同（或改进）的参数，因此 减轻当前（下部）仪器的压力。有许多VA资助的调查人员在 印第安纳波利斯VA将从收购Faxitron UltraFocusDXA数字X射线摄影中受益匪浅 系统，包括Robling（骨质疏松症）、莫伊（慢性肾脏疾病）、Bellido（骨质疏松症）、Roodman博士 （多发性骨髓瘤）、Nakshatri（肌肉减少症/恶病质）、Tholpady（颅面重建）和Evans-Molina （糖尿病/肥胖症）。

This proposal is for the purchase of a Faxitron UltraFocusDXA Digital Radiography System, which will add high resolution dual energy x-ray absorptiometry (DEXA) capabilities to our present imaging capabilities—providing better data on longitudinal effects on bone mass, fat mass, lean mass, and high resolution planar imaging with the use of fewer animals and in less time—and which will also help relieve pressure on our crowded scanning schedule. The laboratories interested in this piece of equipment are involved in a wide range of funded research programs, including bone metabolism, orthopaedics, cancer biology, diabetes, and obesity. With the UltrafocusDXA system, we will be able to scan the mice at a maximum of 48 µm, and a minimum of 6 µm, which will usher in the possibility to measure parts of the skeleton that we are currently unable to do. Using the high resolution planar x-ray capability, we will have the capability to screen mice for tumors, image skeletal fractures, and even assess cortical width and bone geometry. The bed size (camera/detector size) of the on the UltrafocusDXA system is much larger (10 X 15 cm) than the Piximus II system (currently obsolete but the only instrument available) and can accommodate a mouse of any size/weight/age, and even rats. The last mouse DEXA (Lunar's Piximus II system) unit was produced in 2005. Because Lunar shut down production of these research units, technical support is weak and parts are becoming very scarce for repairing the units. Acquisition of the recently introduced Faxitron UltraFocusDXA Digital Radiography System at our VA facility would allow us to get reliable service and parts for our DEXA scanning needs (in addition to better quality, faster, and more versatile capabilities). In addition, the UltraFocusDXA can be used to scan many of the specimens now being scanned on the old Piximus II system, with identical (or improved) parameters, and so relieve pressure on the present (inferior) instrumentation. There are numerous VA-funded investigators at the Indianapolis VA that would benefit greatly from acquisition of the Faxitron UltraFocusDXA Digital Radiography System, including Drs. Robling (osteoporosis), Moe (chronic kidney disease), Bellido (osteoporosis), Roodman (multiple myeloma), Nakshatri (sarcopenia/cachexia), Tholpady (craniofacial reconstruction), and Evans-Molina (diabetes/obesity).