Request for Hysitron TI950 TriboIndenter Nanoindenter with Raman Spectroscopy

索取具有拉曼光谱的 Hysitron TI950 TriboIndenter 纳米压痕仪

• 批准号: 9362915
• 负责人: ALEXANDER G ROBLING
• 金额: --
• 依托单位: RLR VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-01 至 2017-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9362915
• 关键词: Adipose tissue; Area; Basic Science; Biological; Biomedical Engineering; Cachexia; Cancer Biology; Cells; Chemicals; Chronic; Chronic Kidney Failure; Collaborations; Color; Communities; Crystallization; Diabetes Mellitus; Dimensions; Engineering; Equipment; Feedback; Floor; Funding; Goals; Head; Health; Hormones; Humidity; Implant; In Situ; Investigation; Kidney Diseases; Laboratories; Lasers; Lateral; Malignant Neoplasms; Measurement; Measures; Medical center; Microscope; Microscopy; Minerals; Multiple Myeloma; Obesity; Optics; Organ; Orthopedics; Osteocytes; Osteoporosis; Physicians; Positioning Attribute; Productivity; Property; Protein Isoforms; Raman Spectrum Analysis; Research; Research Personnel; Resolution; Sampling; Scanning Probe Microscopy; Scientist; Secure; Signal Transduction; Staging; Stem cells; System; Techniques; Temperature; Testing; Time; Tissues; Transducers; Translations; Veterans; base; bone metabolism; charge coupled device camera; chemical property; data acquisition; detector; experimental study; granite; improved; instrument; instrumentation; interest; kinematics; materials science; mechanical properties; mechanotransduction; microscopic imaging; nanofabrication; nanoindentation; nanomechanical; nanomechanics; nanoscale; next generation; physical property; programs; sarcopenia; sensor; soft tissue; vibration

This proposal is for the purchase of a Hysitron TI950 TriboIndenter/Raman Spectroscopy System, which will add nanoscale materials science capabilities (e.g., nanoindentation, nanofabrication) and high resolution Raman Spectroscopy capabilities (e.g., chemical composition, mineral/crystal isoforms) to our present instrumentation—providing a significant improvement in our ability to measure physical and chemical properties of organs, tissues, cells, compounds, implants, and engineered materials. The laboratories interested in this piece of equipment are involved in a wide range of funded research programs, including bone metabolism, orthopaedics, cancer biology, diabetes, and obesity. With the Hysitron TI950 system, we will be able to measure true material properties of mineralized and soft tissues directly, without the need to estimate parameters based on macro-level tests that have flawed translation to the nano-scale. In addition, the particular instrument we are requesting has the capability to collect Raman spectra and nanoindentation-derived mechanical properties from the same micro-moeity, which will significantly improve the quality of experiments and measurements that we take, and at the same time, will usher in a multitude of new lines of investigation and collaboration that we currently do not enjoy. There are numerous VA-funded investigators at the Indianapolis VA that would benefit greatly from acquisition of the Hysitron TI950 system, including Drs. Robling (osteoporosis/mechano- transduction), Allen (osteoporosis/anti-resorptives), Moe (chronic kidney disease), Bellido (osteoporosis/hormone signaling), Roodman (multiple myeloma), Nakshatri (sarcopenia/cachexia), Chirgwin (myeloma/osteocytes), and March (adipose-derived stem cells). Moreover, the system would allow each of these VA investigators to expand their research programs and begin initiating new collaborations with the large biomedical engineering community on the IU Indianapolis campus, who have expressed significant interest in the system.

该建议是用于购买息肌Ti950 TriboIndenter/Raman光谱 系统，将增加纳米级材料科学能力（例如，纳米构造， 纳米制作）和高分辨率拉曼光谱能力（例如化学 组成，矿物/晶体同工型）至我们目前的仪器 - 提供 我们测量物理和化学特性的能力的显着提高 器官，组织，细胞，化合物，玻璃和工程材料。实验室 对此设备感兴趣的设备涉及广泛的资助研究 计划，包括骨骼代谢，骨科，癌症生物学，糖尿病和 肥胖。使用Hysitron Ti950系统，我们将能够测量真实的材料 无需估算的无需估算的矿化和软时机的特性 基于宏观测试的参数，这些测试有缺陷为纳米级。 此外，我们要求的特定工具具有收集的能力 拉曼光谱和来自同一的纳米构件衍生的机械性能 微型训练，这将显着提高实验质量和 我们进行的测量以及同时将迎来多种新线路 我们目前不喜欢的投资与协作。有很多 VA资助的印第安纳波利斯VA的调查人员将从中受益匪浅 收购Hysitron Ti950系统，包括Drs。挥舞（骨质疏松/机械 - 转移），艾伦（骨质疏松症/抗抑郁剂），MOE（慢性肾脏疾病）， Bellido（骨质疏松/激素信号传导），Roodman（多发性骨髓瘤），Nakshatri （Sarcopenia/Cachexia），Chirgwin（骨髓瘤/骨细胞）和3月（脂肪衍生 干细胞）。此外，该系统将允许这些VA调查人员扩展 他们的研究计划，并开始与大型 IU印第安纳波利斯校园的生物医学工程社区 对系统的重大兴趣。