12th and 13th International Symposia on Neurobiology and Neuroendocrinology of Ag

描述（由申请人提供）：第十二届和第十三届神经生物学和神经内分泌学衰老国际研讨会将于2014年7月27日至8月1日和2016年7月在奥地利布雷根茨举行。这些会议的目的是汇集一组最近在衰老机制研究方面取得重大进展的研究人员，特别强调CNS衰老，神经保护和神经退行性疾病的治疗。具体的主题将包括IGF-1在健康寿命和寿命中的不同作用，以及IGF-1和瘦素在神经保护中的相互作用。几个讲座集中在神经退行性变的各个方面，包括基于细胞的治疗，环境和表观遗传学，DNA损伤和线粒体敏感性，加上一个合并多个模型，以了解神经退行性变。四个讲座将专门讨论细胞衰老和年龄相关疾病的最新进展。一个令人兴奋的老龄化新领域将是一组关于艾滋病毒的演讲的重点。这些讲座将集中在艾滋病毒和神经认知障碍，合并症，免疫衰老和人源化小鼠系统。与器官系统（心脏、肌肉、皮肤）老化相关的机制的讨论将占据另一组讲座。我们故意包括广泛的主题，并聚集了一群通常不会参加同一次会议的科学家。会议的形式是仿照戈登研究会议，并鼓励正式和非正式的讨论所提出的材料。会议记录将作为实验老年学的特刊出版，就像过去11次研讨会一样。强烈鼓励初级研究人员，包括研究生和博士后研究员的参与，该提案寻求资金，为正在接受培训或担任初级教师职位并计划在海报会议上展示其研究结果的美国参与者提供津贴。我们还在寻求对应邀从美国来的发言者的费用提供部分支助。

DESCRIPTION (provided by applicant): The Twelfth and Thirteenth International Symposia on Neurobiology and Neuroendocrinology Aging will be held in Bregenz, Austria July 27-August 1, 2014 and in July 2016. The purpose of these meetings is to bring together a group of investigators who made recent significant advances in the study of mechanisms of aging, with particular emphasis on CNS aging, neuroprotection and treatment of neurodegenerative disease. Specific topics will include the diverse roles of IGF-1 in health span and lifespan and the interplay of IGF-1 and leptin in neuroprotection. Several lectures focus on diverse aspects of neurodegeneration including cell- based therapies, the environment and epigenetics, DNA damage, and mitochondrial sensitivity plus one that merges multiple models to understand neurodegeneration. Four lectures will specifically address recent advances in cellular senescence and age-related disease. An exciting new area of aging will be the focus of a group of presentations on HIV. These talks will focus on HIV and neurocognitive impairment, comorbidities, immunosenescence and the humanized mouse system. Discussion of mechanisms specifically related to aging of organ systems (heart, muscle, skin) will occupy another set of lectures. We purposely include a wide range of topics and assemble a group of scientists that may not normally attend the same meeting. The format of the meeting is modeled after Gordon Research Conferences and encourages formal and informal discussions of the material presented. Proceedings will be published as a special issue of Experimental Gerontology as has been done for the last 11 Symposia. Participation of junior investigators, including graduate students and post-doctoral fellows is strongly encouraged and this proposal seeks funds for providing stipends to those US participants who are in training or are in junior faculty positions and who are planning to present their findings in the poster session. We are also seeking partial support for the expenses of invited speakers from the United States.