University of New Mexico (UNM) Center for Brain Recovery and Repair

 描述（由申请人提供）：脑损伤（如中风和创伤）的幸存者通常会终身残疾，这涉及一系列缺陷，并与巨大的个人和社会成本相关。迫切需要开发可以改善认知和运动功能的有效干预措施，以及可以跟踪个体恢复路径的方法，以开始个性化干预脑损伤后的一系列症状。尤其重要的是可以在受伤后的几个月和几年内应用的方法，因为患者正试图重新融入正常的日常生活。大脑恢复和修复中心将建立一个跨学科的研究人员社区，专注于解决这个问题。该中心将汇集来自不同部门和项目的大量研究人员，并为他们提供集中的设施和资源，以共同开展促进受损大脑细胞修复和促进功能恢复的干预措施。来自UNM内部的既定研究人员，以及来自社区脑损伤项目的关键外部科学顾问和领导，将提供知识和技术专长的核心，并为该领域最有前途的初级教师队伍的发展做出贡献。该中心将专注于将有关脑修复机制的实验室发现转化为临床应用，因此旨在促进临床前和临床研究人员之间的广泛互动。目前缺乏的关键资源将被建立，包括核心设施与切割ede设施的临床和临床前干预和评估。还将为研究者提供B使用其他现有设施和培训的机会，以改善其学习和职业发展。实现这些目标预计将导致多个新项目的校外资金的发展，包括初级教师的第一个R01，以及对中心现有研究人员团队的新的合作奖项。这些将包括来自其他NIH中心的未来计划赠款，以及强有力的机构支持，将在目前的奖励期之后保持中心的增长。显著增强的研究能力也将提供给新墨西哥州更大的脑和行为健康调查人员群体，以及其他IDEA州的调查人员。这些结果预计将产生重要的积极影响，因为它们将大大加快发现和采用干预措施，这些干预措施是IDEA社区中大量患有脑损伤破坏性后果的人迫切需要的。

 DESCRIPTION (provided by applicant): Survivors of brain injuries such as stroke and trauma often endure life-long disabilities, which span a spectrum of deficits and which are associated with enormous individual and societal costs. There is an urgent need to develop effective interventions that can improve cognitive and motor function, as well as methods that can track individual recovery paths to begin to personalize intervention for the range of symptoms the follow brain injury. Especially critical are approaches that can be applied in the months and years after the injury, as patients are attempting to reintegrate into normal daily life. The Cente for Brain Recovery and Repair will develop an interdisciplinary community of investigators focused on addressing this issue. The Center will bring together a critical mass of investigators from different departments and programs, and provide them with centralized facilities and resources needed to work together on interventions that promote cellular repair of damaged brain, and promote recovery of function. Established investigators from within UNM, together with key external scientific consultants and leadership from community brain injury programs will provide a nucleus of intellectual and technical expertise, and contribute to the development of a cohort of the most promising junior faculty in this field. The Center will focus on moving laboratory discoveries about brain repair mechanisms into clinical application, and is therefore structured to promote extensive interaction between preclinical and clinical investigators. Key resources that are currently lacking will be established, including core facilities with cutting ede facilities for clinical and preclinical interventions and assessments. Investigators will be also b provided with access to other existing facilities and training that can improve their studies and career development. Achieving these aims is expected to lead to development of extramural funding of multiple new programs, including first R01s for junior faculty, and new collaborative awards to teams of established investigators in the Center. These will include future program grants from other NIH centers which, together with strong institutional support, will maintain growth of the Center beyond the period of the current award. Significantly enhanced research capabilities will also be available for a larger constituency of brain and behavioral health investigators in New Mexico, and investigators in other IDeA states. Such outcomes are expected to have an important positive impact, as they will greatly accelerate the discovery and adoption of interventions that are urgently needed for large numbers of individuals in IDeA communities living with the devastating consequences of brain injury.