University of New Mexico (UNM) Center for Brain Recovery and Repair

新墨西哥大学 (UNM) 脑恢复和修复中心

• 批准号: 10679079
• 负责人: Claude W Shuttleworth
• 金额: $ 220.66万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10679079
• 关键词: Acceleration; Acute Brain Injuries; Address; Adoption; Animal Experimentation; Basic Science; Behavior; Brain; Brain Injuries; Caring; Cell Nucleus; Centers of Research Excellence; Clinical; Clinical Investigator; Cognitive; Collaborations; Communities; Complement; Core Facility; Dedications; Development; Electrophysiology (science); Ensure; Evolution; Exposure to; Extramural Activities; Faculty; Family; Fertilization; Funding; Goals; Grant; Home; Hospitals; Image; Individual; Inpatients; Institution; Interdisciplinary Study; Intervention; Laboratories; Leadership; Life; Mentors; Methods; Mexican; Motor; Neuroanatomy; Neurons; New Mexico; Outcome; Outpatients; Patients; Phase; Physiology; Positioning Attribute; Quality of life; Recovery; Recovery of Function; Research; Research Personnel; Resource Sharing; Resources; Rodent; Rodent Model; Services; Severities; Stroke; Structure; Students; Survivors; Time; Training; Trauma; Traumatic Brain Injury; Traumatic injury; Universities; Work; behavioral health; brain health; brain research; career; clinical application; cognitive control; cognitive testing; cohort; community living; cost; data streams; disability; effective intervention; effective therapy; equipment acquisition; faculty mentor; improved; injured; innovation; interdisciplinary collaboration; mortality; multimodal data; neurophysiology; novel; personalized approach; pre-clinical; prevent; programs; repaired; senior faculty; societal costs; success; symposium; tenure track

SUMMARY Survivors of brain injuries such as stroke and trauma often endure life-long disabilities, which span a spectrum of deficits and are associated with enormous individual and societal costs. There is an urgent need to develop effective interventions that can improve cognitive and motor outcomes, especially individualized approaches that target specific disruptions of brain physiology or circuits. The Center for Brain Recovery and Repair was established in Phase I as an interdisciplinary community of investigators to address these issues. A cohort of junior faculty successfully launched new independent research programs and have remained centrally active within the Center. Together with core leadership and other established investigators from diverse departments and programs across campus, we have established a highly interactive nucleus, working closely together in a physical home in Domenici Hall. Phase II activities build on this progress, by adding additional layers of mentored faculty, projects and resources required to ensure a self-sustaining, high impact Center. The Center will maintain its successful focus on moving laboratory discoveries about brain injury mechanisms into clinical application, and will therefore continue to emphasize a structure that promotes extensive mentoring and interaction between preclinical and clinical investigators. The physical home in Domenici Hall will be enhanced, to strengthen state-of-the-art facilities for both rodent studies and clinical interventions and assessment. Recordings from brain-injured patients in the neuro intensive care unit will also be studied in our Domenici Hall core facilities in Phase II, to address novel, actionable mechanisms earlier in the progression of brain injury. Innovative combinations of electrophysiology, imaging and cognitive assessment will be led by both the clinical and preclinical cores, with extensive cross-fertilization of ideas and approaches. An exciting set of projects using these cores will be led by junior faculty from different departments, addressing different severities and consequences of traumatic brain injury. An expanded pilot program, together with new partnerships and tenure-track hires will further increase the critical mass of investigators in the Center, supporting fiscal sustainability and increasing competitiveness for center-level support with additional extramural grants. The Center will leverage existing facilities and trainings at UNM, and expand valuable collaborations with regional IDeA programs for pipeline development and resource sharing. The significantly enhanced research capabilities will thus be available for a larger constituency of brain and behavioral health investigators in New Mexico, and investigators in other IDeA states. Such outcomes are expected to have an important positive impact, as they will greatly accelerate the discovery and adoption of interventions that are urgently needed for large numbers of individuals in IDeA communities living with the devastating consequences of brain injury.

总结 脑损伤（如中风和创伤）的幸存者往往会终身残疾， 这是一系列赤字，并与巨大的个人和社会成本有关。目前迫切 需要制定有效的干预措施，以改善认知和运动结果，特别是 针对大脑生理或回路的特定中断的个性化方法。中心 大脑恢复和修复是在第一阶段建立的，作为一个跨学科的研究者社区， 以解决这些问题。一群初级教师成功地启动了新的独立研究项目 并一直活跃在中心内。与核心领导层和其他既定 来自校园不同部门和项目的调查人员，我们已经建立了一个高度 互动的核心，密切合作，在一个物理家在多梅尼西大厅。第二阶段活动建立 在这一进展，通过增加额外的指导教师，项目和所需的资源，以确保 一个自我维持的高影响力的中心该中心将保持其成功的重点是移动实验室 关于脑损伤机制的发现进入临床应用，因此将继续强调 促进临床前和临床研究者之间广泛指导和互动的结构。 Domenici Hall的物理家将得到加强，以加强最先进的设施， 研究和临床干预及评估。神经科脑损伤病人的记录 在第二阶段，我们还将在Domenici Hall核心设施中研究重症监护室， 在脑损伤进展的早期可操作的机制。创新组合， 电生理学、成像和认知评估将由临床和临床前核心领导， 通过广泛的思想和方法的相互交流。一组令人兴奋的使用这些核心的项目将 由来自不同部门的初级教师领导，解决不同的严重程度和后果， 创伤性脑损伤扩大试点计划，以及新的合作伙伴关系和终身教职员工 将进一步增加中心调查人员的临界质量，支持财政可持续性， 通过额外的校外赠款提高中心一级支持的竞争力。该中心将 利用UNM的现有设施和培训，并扩大与区域IDEA的宝贵合作 管道开发和资源共享计划。研究能力显著增强 因此，新墨西哥州的大脑和行为健康调查人员将可获得更大的选区， 其他州的研究人员。预计这些成果将产生重要的积极影响，因为它们 将大大加快发现和采用大量迫切需要的干预措施， 生活在IDEA社区中的个人遭受脑损伤的毁灭性后果。

项目成果

Extended Erythropoietin Treatment Prevents Chronic Executive Functional and Microstructural Deficits Following Early Severe Traumatic Brain Injury in Rats.

• DOI: 10.3389/fneur.2018.00451
• 发表时间: 2018
• 期刊: Frontiers in neurology
• 影响因子: 3.4
• 作者: Robinson S;Winer JL;Chan LAS;Oppong AY;Yellowhair TR;Maxwell JR;Andrews N;Yang Y;Sillerud LO;Meehan WP 3rd;Mannix R;Brigman JL;Jantzie LL
• 通讯作者: Jantzie LL

The Patient Repository for EEG Data + Computational Tools (PRED+CT).

• DOI: 10.3389/fninf.2017.00067
• 发表时间: 2017
• 期刊: Frontiers in neuroinformatics
• 影响因子: 3.5
• 作者: Cavanagh JF;Napolitano A;Wu C;Mueen A
• 通讯作者: Mueen A

Neural correlates of cognitive control deficits in pediatric mild traumatic brain injury.

• DOI: 10.1002/hbm.26504
• 发表时间: 2023-12-01
• 期刊: HUMAN BRAIN MAPPING
• 影响因子: 4.8
• 作者: van Der Horn, Harm J.;Dodd, Andrew B.;Wick, Tracey V.;Robertson-Benta, Cidney R.;Mcquaid, Jessica R.;Hittson, Anne K.;Ling, Josef M.;Zotev, Vadim;Ryman, Sephira G.;Erhardt, Erik B.;Phillips, John P.;Campbell, Richard A.;Sapien, Robert E.;Mayer, Andrew R.
• 通讯作者: Mayer, Andrew R.

Prenatal alcohol exposure alters mRNA expression for stress peptides, glucocorticoid receptor function and immune factors in acutely stressed neonatal brain.

• DOI: 10.3389/fnins.2023.1203557
• 发表时间: 2023
• 期刊: FRONTIERS IN NEUROSCIENCE
• 影响因子: 4.3
• 作者: Ruffaner-Hanson, Chaselyn D. D.;Fernandez-Oropeza, Annette K. K.;Sun, Melody S. S.;Caldwell, Kevin K. K.;Allan, Andrea M. M.;Savage, Daniel D. D.;Valenzuela, C. Fernando;Noor, Shahani;Milligan, Erin D. D.
• 通讯作者: Milligan, Erin D. D.

Cognitive states influence dopamine-driven aberrant learning in Parkinson's disease.

• DOI: 10.1016/j.cortex.2017.02.021
• 发表时间: 2017-05
• 期刊: Cortex; a journal devoted to the study of the nervous system and behavior
• 作者: Cavanagh JF;Mueller AA;Brown DR;Janowich JR;Story-Remer JH;Wegele A;Richardson SP
• 通讯作者: Richardson SP