University of New Mexico (UNM) Center for Brain Recovery and Repair

新墨西哥大学 (UNM) 脑恢复和修复中心

• 批准号: 10400522
• 负责人: Claude W Shuttleworth
• 金额: $ 21.69万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10400522
• 关键词: Acute Brain Injuries; Address; Adoption; Animal Experimentation; Basic Science; Behavior; Brain; Brain Injuries; Caring; Cell Nucleus; Centers of Research Excellence; Clinical; Clinical Investigator; Cognitive; Collaborations; Communities; Complement; Core Facility; Development; Electrophysiology (science); Ensure; Evolution; Exposure to; Extramural Activities; Faculty; Family; Fertilization; Funding; Goals; Grant; Home; Hospitals; Image; Individual; Inpatients; Institution; Intensive Care Units; Interdisciplinary Study; Intervention; Laboratories; Leadership; Life; Mentors; Methods; Mexican; Motor; Neurons; New Mexico; Outcome; Outpatients; Patients; Phase; Physiology; Positioning Attribute; Quality of life; Recovery; Recovery of Function; Research; Research Personnel; Resource Sharing; Resources; Rodent; Rodent Model; Services; Severities; Stroke; Structure; Students; Survivors; Time; Training; Trauma; Traumatic Brain Injury; Traumatic injury; Universities; Work; base; behavioral health; brain health; brain research; career; clinical application; cognitive control; cognitive testing; cohort; community living; cost; data streams; disability; effective intervention; effective therapy; equipment acquisition; faculty mentor; improved; injured; innovation; interdisciplinary collaboration; mortality; multimodal data; neurophysiology; novel; personalized approach; pre-clinical; prevent; programs; repaired; senior faculty; societal costs; success; symposium; tenure track

SUMMARY Survivors of brain injuries such as stroke and trauma often endure life-long disabilities, which span a spectrum of deficits and are associated with enormous individual and societal costs. There is an urgent need to develop effective interventions that can improve cognitive and motor outcomes, especially individualized approaches that target specific disruptions of brain physiology or circuits. The Center for Brain Recovery and Repair was established in Phase I as an interdisciplinary community of investigators to address these issues. A cohort of junior faculty successfully launched new independent research programs and have remained centrally active within the Center. Together with core leadership and other established investigators from diverse departments and programs across campus, we have established a highly interactive nucleus, working closely together in a physical home in Domenici Hall. Phase II activities build on this progress, by adding additional layers of mentored faculty, projects and resources required to ensure a self-sustaining, high impact Center. The Center will maintain its successful focus on moving laboratory discoveries about brain injury mechanisms into clinical application, and will therefore continue to emphasize a structure that promotes extensive mentoring and interaction between preclinical and clinical investigators. The physical home in Domenici Hall will be enhanced, to strengthen state-of-the-art facilities for both rodent studies and clinical interventions and assessment. Recordings from brain-injured patients in the neuro intensive care unit will also be studied in our Domenici Hall core facilities in Phase II, to address novel, actionable mechanisms earlier in the progression of brain injury. Innovative combinations of electrophysiology, imaging and cognitive assessment will be led by both the clinical and preclinical cores, with extensive cross-fertilization of ideas and approaches. An exciting set of projects using these cores will be led by junior faculty from different departments, addressing different severities and consequences of traumatic brain injury. An expanded pilot program, together with new partnerships and tenure-track hires will further increase the critical mass of investigators in the Center, supporting fiscal sustainability and increasing competitiveness for center-level support with additional extramural grants. The Center will leverage existing facilities and trainings at UNM, and expand valuable collaborations with regional IDeA programs for pipeline development and resource sharing. The significantly enhanced research capabilities will thus be available for a larger constituency of brain and behavioral health investigators in New Mexico, and investigators in other IDeA states. Such outcomes are expected to have an important positive impact, as they will greatly accelerate the discovery and adoption of interventions that are urgently needed for large numbers of individuals in IDeA communities living with the devastating consequences of brain injury.

摘要 中风和创伤等脑损伤的幸存者通常遭受终身残疾，其持续时间为 这是一系列赤字，并与巨大的个人和社会成本有关。有一件急事 需要制定有效的干预措施，以改善认知和运动结果，尤其是 针对大脑生理或回路的特定干扰的个性化方法。该中心为 大脑恢复和修复是在第一阶段建立的，作为一个跨学科的调查社区，以 解决这些问题。一批初级教员成功地启动了新的独立研究项目 并在中心内保持着中心的活跃状态。与核心领导层和其他公认的 来自校园不同部门和项目的调查人员，我们已经建立了一个高度 互动核心，在多梅尼奇大厅的一个实体之家密切合作。第二阶段活动建设 关于这一进展，通过增加额外层次的指导教师、项目和所需资源来确保 一个自给自足、高影响力的中心。该中心将继续成功地将重点放在搬迁实验室上 脑损伤机制的发现转化为临床应用，因此将继续强调 促进临床前和临床研究人员之间的广泛指导和互动的结构。 多梅尼奇大厅的实体之家将得到加强，以加强这两种啮齿动物的最先进设施 研究、临床干预和评估。脑损伤患者在神经科的录音 在第二阶段，我们还将在多梅尼奇大厅的核心设施中研究重症监护病房，以解决新的， 在脑损伤进展的早期可操作的机制。创新的组合 电生理学、成像和认知评估将由临床和临床前核心共同领导， 思想和方法的广泛交融。使用这些核心的一系列令人兴奋的项目将 由来自不同部门的初级教员领导，解决不同的严重程度和后果 创伤性脑损伤。扩大试点计划，以及新的合作伙伴关系和终身教职轨道招聘 将进一步增加该中心调查人员的临界人数，支持财政可持续性和 通过额外的校外赠款提高中央一级支持的竞争力。该中心将 利用UNM的现有设施和培训，并扩大与区域IDEA的宝贵合作 管道开发和资源共享计划。显著增强的研究能力 因此，将适用于新墨西哥州更多的大脑和行为健康研究人员，以及 其他想法国家的调查人员。这些结果预计将产生重要的积极影响，因为它们 将极大地加速发现和采用大量急需的干预措施 理想社区中的个人生活在脑损伤的毁灭性后果中。