Center on the Demography of Aging

描述（由申请人提供）：宾夕法尼亚大学人口老龄化研究中心（PARC）提议将其现有的P30中心延续5年，2014-2019年有以下五个签名主题：i)老年人的健康、疾病和死亡风险，包括种族和性别差异，包括时期和队列风险及其潜在的社会和生物学机制；（二）早期生活条件和老年人健康、行为和福祉：探索可能对我们如何变老至关重要的早期发展环境，包括营养、传染病、社会支持、教育以及产前和童年时期的基因-环境相互作用；iii)全球老龄化：影响全球老年人福祉的社会文化、经济和环境环境；生活方式改变对迅速转型的发展中国家的健康和老龄化的影响；iv)研究生命史的生物人口统计学和进化方法，包括收集和分析衰老的代谢和遗传生物标志物的创新分析方法，评估解释人类衰老轨迹的非人类动物模型，以及使用进化框架重新解释数据和产生新的可测试的假设；（五）国内/国际对老年人福祉的看法，强调生命周期决策和老年经济保障及其与不断变化的工作模式、家庭支持、储蓄和养恤金、健康保险和保健系统的相互作用。注意到目前的预算情况，帕洛阿尔托研究中心改组和精简了其业务，建议建立一个规模较小但效率很高的生产中心

DESCRIPTION (provided by applicant): The Population Aging Research Center (PARC) at the University of Pennsylvania proposes a 5-year continuation of its existing P30 Center, with the following five signatures themes for 2014-2019: i) Health, disease, and mortality risks at older ages, incorporating race and gender differences, including period and cohort risks and their underlying social and biological mechanisms; ii) Early-life conditions and older adult health, behavior, and well-being: an exploration of early developmental circumstances that may be crucial for shaping how we grow old, including nutrition, infectious disease, social support, education, and gene-environment interactions prenatally and during childhood; iii) Global aging: sociocultural, economic, and environmental circumstances impacting the well-being of older individuals around the world; consequences for health and aging of lifestyle changes on rapidly transitioning developing countries; iv) Biodemographical and evolutionary approaches to life history, including innovative analytic methodologies for collecting and analyzing metabolic, and genetic biomarkers of aging, evaluation of non-human animal models for explaining human aging trajectories, and use of evolutionary frameworks for re-interpreting data and generating new testable hypotheses; v) Domestic/international perspectives on well-being at older ages, emphasizing lifecycle decision-making and old-age financial security and their interactions with changing work patterns, family support, savings and pensions, health insurance, and health care systems. Attentive to the current budgetary situation, PARC has restructured and streamlined its operations to propose a smaller, but highly efficient and productive Center that is the hub of research activity of 35 Research Associates working on aging-related issues. Three Cores are proposed: Core A: "Administrative & Research Support"(Valeggia, PI) to provide dedicated administrative and data management services to Associates, convene an External Advisory Committee, and establish an initiative aimed at increasing the number of NIH/NIA grant applications, especially from Pilot projects Pi's; Core B: "Program Development" (Valeggia, PI) to sustain & evaluate the Pilot Program; support is requested for three 2-year pilots that emphasize one or more signature themes; Core C: "External Innovative Network" (Behrman, PI) to expand and strengthen five research & collaboration networks: the Latin American Network on Aging (LANA), the Network on Aging in Sub-Saharan Africa (NASSA), the Evolutionary Network (EvoDemo), the Network on Effects of Early Life on Mature Adults (NEELMA), and the Network on Migration Advantage (NeMA).