Developmental Nephrology

儿童肾脏病学基础和转化研究的重点包括：先天性和遗传性肾脏疾病，肾小球肾炎，急性肾损伤，慢性肾脏和终末期肾脏疾病，以及发育性肾功能评估。解决这些领域的内在需求是需要一批训练有素的儿科肾病研究人员，他们分别掌握基础科学、转化科学和团队科学的最新进展。阿尔伯特·爱因斯坦医学院的发育肾病学培训项目一直以来都提供了培训经验，以促进儿童肾病学医师调查员的发展，他们将满足该亚专科的学术需求。毕业生将准备诊断和管理儿科肾脏疾病，了解液体和电解质调节的生理学，重点是肾脏在健康和疾病中的发育和成熟。与临床问题相关的研究项目包括儿童肾病综合征的分子特征、儿童移植中的免疫抑制和同种异体移植排斥反应、骨病和生长迟缓的机制、儿童高血压及其心血管危险因素的研究。因此，我们的毕业生将准备通过最现代的调查方法来解决本专业的主要问题。他们将获得必要的基础研究方法的经验，以阐明诸如正常和异常肾脏发育的细胞和分子机制、细胞极性、自噬和表观遗传学在肾脏成熟和肾脏疾病中的作用等不同主题。与肾内科、医学部、儿科、发育与分子生物学等部门的研究人员持续合作，以及蒙蒂菲奥里/爱因斯坦临床与转化研究所核心设施提供的广泛基础设施和支持，为研究培训和教育提供了机会，促进了学员的职业发展。在肾脏病的基础和临床/转化研究领域的联合会议和来自美国和国外的著名研究人员的讲座有助于学员获得知识和欣赏批判性科学分析的重要性。肾脏生理学、研究设计、生物伦理学、生物统计学、肾脏病理学、转化研究核心能力的必修课程、考试以及参加临床研究培训计划和转化医学新计划的机会，进一步补充了学员的经验。

DESCRIPTION (provided by applicant): Priorities in pediatric nephrology basic and translational research include: congenital and hereditary disorders of the kidney, glomerulonephritides, acute kidney injury, chronic kidney and end-stage kidney diseases, and developmental renal function assessment. Inherent in addressing these areas is the need for an outstanding cadre of well-trained pediatric nephrology investigators skilled in the latest advances in basic, translational and team sciences respectively. The training program in Developmental Nephrology at the Albert Einstein College of Medicine has historically provided the training experience to foster development of pediatric nephrology physician-investigators who will meet the academic needs of the subspecialty. Graduates will be prepared to diagnose and manage pediatric kidney disorders, understand the physiology of fluid and electrolyte regulation, with emphasis on the development and maturation of the kidney in health and disease. Research projects, related to clinical issues, involve studies into the molecular characterization of nephrotic syndrome of childhood, immunosuppression and allograft rejection in pediatric transplantation, mechanisms of bone disease and growth retardation, pediatric hypertension and its cardiovascular risk factors. Thus, our graduates will be prepared to tackle the prevailing issues of our sub-specialty by the most modern methods of investigation available. They will have acquired experience in basic research methodology necessary to elucidate such diverse subjects as the cellular and molecular mechanisms responsible for normal and abnormal kidney development, cell polarity, the roles of autophagy and epigenetics in renal maturation and renal disease. Continued collaboration with investigators in the Division of Nephrology, and other divisions of the Department of Medicine, the Departments of Pediatrics, and Developmental & Molecular Biology, and the extensive infrastructure and support offered by the Core Facilities at Montefiore/Einstein's Institute for Clinical and Translational Research provide opportunities for research training and education that foster the career development of the trainees. Combined conferences in basic and clinical/translational research areas in nephrology and lectures given by prominent investigators from US and abroad facilitate the trainee's acquisition of knowledge and appreciation of the importance of critical scientific analysis. Required courses in renal physiology, research design, bioethics, biostatistics, renal pathology, translational research core competencies, examinations and the opportunity to enroll in the Clinical Research Training Program and a new program in translational medicine, complement further the trainee's experience.