COBRE for the Center for Molecular Medicine

这项科布雷第三阶段提案旨在进一步发展该大学的分子医学中心 肯塔基州。该中心专注于旨在了解分子机制的研究 与人类疾病有关，重点是癌症、神经退行性疾病、糖尿病和 心血管疾病。我们建议将开发的研究基础设施过渡到独立 在之前的科布雷投资中。我们科布雷资助的分子医学中心已经有了一些 成功。在之前的资助期间，来自12个不同部门和中心的30名初级教员 被资助为科布雷项目或试点赠款个人投资项目。这些被指导的教职员工获得了27项NIH ROI拨款，11项 NIH的其他赠款，以及其他41项同行审查的校外赠款。科布雷资助的初级教员 发表研究论文400余篇。这些和其他的成功在很大程度上可以归因于 强大的指导计划，出色的机构支持，以及科学核心的可用性 与中心相关联。对于这一应用，我们建议将分子医学中心 及其三大科学核心对NIH/NIGMS的独立支持以及对核心的增强和升级 技术。值得注意的是，我们原来的两个核心已经或即将过渡到独立； 由这个Cobre开发的蛋白质组学核心现在是大学收费服务核心，Cobre 支持的成像核心即将成为部门支持的核心。在拟议的五年计划期间 在过渡期内，我们将增加与该中心相关的临界教职员工数量，并继续 加强它的核心。代金券的使用将促进核心使用，试点赠款将发展研究 合作和竞争性拨款申请。行政核心将作为以下工作的重点 赠款并与方案协调员和内部咨询委员会一起，将作为 该中心的运营部门。一个由世界知名科学家组成的外部咨询委员会将 提供对中心的持续评估和评估。持续的机构承诺将确保 计划性增长和长期可持续性。

This COBRE Phase III proposal aims to further develop the Center for Molecular Medicine at the University of Kentucky. This Center focuses on research aimed at understanding the molecular mechanisms associated with human disease with emphases on cancer, neurodegenerative diseases, diabetes, and cardiovascular diseases. We propose to transition to independence the research infrastructure developed during previous COBRE funding. Our COBRE funded Center for Molecular Medicine has had a number of successes. During the previous funding period 30 junior faculty from 12 different departments and centers were funded as COBRE project or pilot grant PIs. These mentored faculty received 27 NIH ROI grants, 11 other NIH grants, and 41 other peer-reviewed extramural grants. The COBRE-supported junior faculty published more than 400 research papers. These and other successes can in large part be attributed to a strong mentoring program, excellent institutional support, and the availability of the scientific cores associated with the Center. For this application, we propose to transition the Center for Molecular Medicine and its three scientific cores to independence of NIH/NIGMS support and to enhance and upgrade core technologies. It is worth noting that two of our original cores have or soon will transition to independence; the Proteomics core developed by this COBRE is now a University fee-for-service core, and the COBRE supported Imaging core is soon to become a department supported core. During the proposed five-year transition period we will increase the critical mass of faculty associated with the Center and continue to enhace its Cores. The use of vouchers will promote core usage and pilot grants will develop research collaborations and competitive grant submissions. The Administrative Core will serve as the focal point of the grant and in conjunction with the Program Coordinator and Internal Advisory Committee will serve as the operational arm of the Center. An External Advisory Committee, consisting of world-renown scientists will provide ongoing assessment and evaluation of the Center. Continuing Institutional commitments will ensure programmatic growth, and long-term sustainability.