2017 Muscle: Excitation-Contraction Coupling Gordon Research Conference and Gordon Research Seminar

摘要 这是一项部分支持唯一一次主要的国家和/或国际会议的提案，专门讨论 兴奋/收缩耦合以及这一关键过程中的缺陷是如何导致肌肉疾病的。肌肉： 激发-收缩耦合(ECC)戈登研究会议(GRC)将于6月4日至6月9日举行， 2017年在瑞士Les Diablerets的Les Diablerets会议中心举行。开发了GRC程序 由ECC研究领域的领导者组成的执行组织委员会，其中包括赫克托·H·瓦尔迪瓦博士 (密歇根大学)、伊莎贝尔·马蒂(格勒诺布尔神经科学研究所)和菲利普·范·佩蒂姆 (不列颠哥伦比亚大学)。2017年肌肉的两个首要目标：兴奋-收缩 联合GRC是：目标1：讨论和批判性地评估关于 控制ECC的分子机制以及这一过程在肌肉疲劳、萎缩、 骨质疏松症、代谢性疾病以及遗传形式的骨骼和心肌疾病。 目标2：通过提供一个平台，提高初级调查员在外地的知名度和领导力 学生、博士后研究员和新的独立研究人员展示他们的工作，以及互动 并与老牌高级调查人员建立网络。2017年GRC会议将由~30名演讲者、~18名演讲者组成 讨论领袖和~13张海报演示文稿。科学会议将集中在结构研究上 ECC装置，ECC分子机制和调控的新见解，新的鉴定 治疗目标，以及肌肉疲劳、骨质疏松症和骨骼的创新治疗的发展 以及对美国数百万人造成不利影响的心肌疾病。这是第二次 在本次GRC会议之前，将为研究生举办为期两天的戈登研究研讨会(GRS 和博士后研究员。此外，在GRC期间的每一次会议上，将有一名年轻的调查员与 一名高级调查员担任联合讨论负责人。创新的《海报快闪会》和《这才刚进来》 扬声器插槽将用于突出最新的新闻。这些创新的计划元素还将 最大限度地提高海报会议的知名度，并加强有前途的年轻人的融合和曝光 GRC期间在现场的调查人员。我们预计这次会议将吸引150-200名基础和临床 所有职业阶段、性别、种族、遗产、研究学科、专业背景的科学家 (学术、工业、政府)和地理位置。我们的总体目标是促进：1)开放 对话和交流，2)接触和职业发展有前途的年轻调查人员在 领域，3)对ECC机制的基本理解以及这一过程中的缺陷如何导致 损害骨骼肌和心肌的性能，以及4)开发新的有效的 对抗骨骼和心肌疾病的治疗方法。

ABSTRACT This is a proposal for partial support of the only major national and/or international meeting dedicated to excitation/contraction coupling and how defects in this critical process underlie muscle disease. The Muscle: Excitation-Contraction Coupling (ECC) Gordon Research Conference (GRC) will meet from June 4 – June 9, 2017 at Les Diablerets Conference Center in Les Diablerets, Switzerland. The GRC program was developed by an Executive Organizing Committee consisting of leaders in ECC research including Drs. Héctor H. Valdivia (University of Michigan), Isabelle Marty (Grenoble Institute of Neurosciences), and Filip Van Petegem (University of British Columbia). The two overarching objectives of the 2017 Muscle: Excitation-Contraction Coupling GRC are: Objective 1: To discuss and critically evaluate new breakthroughs regarding the molecular mechanisms that control ECC and how this process is altered in muscle fatigue, atrophy, sarcopenia, metabolic disease, and genetically-inherited forms of skeletal and cardiac muscle disease. Objective 2: To promote visibility and leadership of junior investigators in the field by providing a platform for students, postdoctoral fellows, and new independent investigators to present their work, as well as to interact and network with established senior investigators. The 2017 GRC conference will consist of ~30 speakers, ~18 Discussion Leaders, and ~13 poster presentations. Scientific sessions will focus on structural studies of the ECC apparatus, new insights into the molecular mechanisms and regulation of ECC, identification of new therapeutic targets, and the development of innovative treatments for muscle fatigue, sarcopenia, and skeletal and cardiac muscle disorders that adversely impact millions of individuals in the US. For the second time for this GRC, the meeting will be preceded by a two-day Gordon Research Seminar (GRS) for graduate students and postdoctoral fellows. In addition, for each session during the GRC a young investigator will be paired with a senior investigator to serve as Co-Discussion Leaders. Innovative “Poster Flash Sessions” and “This Just In” speaker slots will be used to highlight late-breaking news. These innovative program elements will also maximize poster session visibility, as well as to enhance the integration and exposure of promising young investigators in the field during the GRC. We expect that this conference will attract 150-200 basic and clinical scientists across all career stages, genders, races, heritages, research disciplines, professional affiliations (academic, industrial, government), and geographical locations. Our overall aim is to promote: 1) open dialogue and communication, 2) exposure and career advancement of promising young investigators in the field, 3) fundamental understanding in the mechanisms of ECC and how defects in this process lead to compromised skeletal and cardiac muscle performance, and 4) the development of novel and effective therapies to combat skeletal and cardiac muscle disorders.