Cardiovascular Imaging in Ischemic Heart Disease

项目总结/摘要 申请人Udo Hoffmann MD MPH是哈佛医学院的放射学教授， 麻省总医院放射科心血管影像科。霍夫曼医生已经证实 一个以患者为导向的研究（POR）计划，结合了创新的翻译，临床和成果 研究方法，以证明先进的心血管成像的价值。霍夫曼博士发表了 约380篇同行评审论文，其中许多发表在顶级医学期刊上，并已收到 自2005年以来，持续的独立，同行评审的POR NIH资助。他是为数不多的 成员在哈佛医学院谁是PI和主任的一个非常成功的NHLBI资助的T- 32程序（心脏MR和CT研究）和K24的接受者。霍夫曼博士成功地指导了 超过60名临床研究人员，其中大多数目前在主要学术中心担任教职 并积极进行POR。此外，霍夫曼博士成功地完成了所有的指导和科学。 第一个K24奖项的目标。总的来说，这些成就证明了霍夫曼博士长期以来 对POR的热情和承诺。他出色的出版、资助和指导记录， 目前和计划中的研究支持为实现这一目标提供了良好的基础 K24奖“缺血性心脏病心血管成像”的竞争性更新。霍夫曼医生 提出了一个指导和研究计划，利用过去的协同作用，正在进行的，和未来的高度 创新的独立研究项目，提供心脏MR的教育和培训机会 CT PET计划、T32心血管成像培训计划、哈佛CTSA和哈佛 公共卫生学院。解决K24奖的具体目标是使霍夫曼博士 1）将25%的时间用于指导基于NIH或同等资助项目的临床研究者， “缺血性心脏病的心血管成像”，2）指导初级和中级临床研究人员 目标是将他们培养成能够成功竞争同行评审赠款的临床研究人员， 3）继续扩大POR计划，将转化，临床和结果研究相结合， 培养心血管成像及其他领域临床研究的未来领导者。研究计划 包括四个具体目标：1）确定他汀类药物治疗对冠心病患者冠状动脉粥样硬化的影响， 800例HIV患者随机接受他汀类药物治疗与安慰剂治疗，2）为了确定是否高 在4600例临床怀疑CAD的患者中，危险冠状动脉斑块预测心血管事件，3） 确定CT血流储备分数在稳定型和急性胸痛患者中的成本效益，以及4）使用 放射组学用于识别新的影像学标记物，以预测参与者的心血管事件 心脏病研究。

Project Summary/Abstract The applicant Udo Hoffmann MD MPH is a Professor of Radiology at Harvard Medical School and the Chief of the Division for Cardiovascular Imaging in the Department of Radiology at MGH. Dr. Hoffmann has established a patient oriented research (POR) program that combines innovative translational, clinical, and outcomes research methods to demonstrate the value of advanced cardiovascular imaging. Dr. Hoffmann has published approximately 380 peer reviewed papers, among them many in premier medical journals and has received continued independent, peer-reviewed POR NIH funding since 2005. He is among the very few faculty members at Harvard Medical School who are both the PI and Director of a highly successful NHLBI funded T- 32 program (Cardiac MR and CT Research) and a recipient of a K24. Dr. Hoffmann has successfully mentored more than 60 clinical investigators, most of which currently hold faculty positions in major academic centers and actively perform POR. Moreover, Dr. Hoffmann has successfully accomplished all mentoring and scientific goals of the first K24 award period. Overall, these achievements document Dr. Hoffmann's long standing passion and commitment to POR. His excellent publication, funding, and mentoring record together with his current and planned research support provide an excellent foundation to accomplish the aims of this competitive renewal of the K24 Award “Cardiovascular Imaging in Ischemic Heart Disease”. Dr. Hoffmann proposes a mentoring and research plan that utilizes the synergies of past, ongoing, and future highly innovative independent research projects with educational and training opportunities offered by the cardiac MR CT PET Program, the T32 training program in cardiovascular imaging, the Harvard CTSA, and the Harvard School of Public Health. The specific aims addressing the charge of the K24 Award are to enable Dr. Hoffmann to: 1) dedicate 25% of his time to mentor clinical investigators based on NIH or equivalent funded projects in “Cardiovascular Imaging in Ischemic Heart Disease”, 2) to mentor junior and mid-career clinical investigators with the goal to develop them into clinical researchers who can successfully compete for peer reviewed grants, and 3) to continue to expand a POR program that combines translational, clinical, and outcomes research to develop future leaders in clinical research in cardiovascular imaging and beyond. The research plan encompasses four specific aims: 1) To determine the effects of statin treatment on coronary atherosclerosis in HIV patients in 800 patients with HIV randomized to statin therapy vs. placebo, 2) To determine whether high risk coronary plaque predicts cardiovascular events in 4600 patients with clinical suspicion of CAD, 3) To determine the cost effectiveness of CT FFR in patients with stable and acute chest pain, and 4) To use Radiomics to identify novel imaging markers predicting cardiovascular events in participants of the Framingham Heart Study.