Training in HIV Replication and Pathogenesis

虽然艾滋病毒/艾滋病流行病仍在继续，但艾滋病毒感染的发病率已经下降， 部署抗病毒药物和多种预防模式。最近的研究成果， 彻底消灭艾滋病毒，开发新的疫苗和治疗方法，以及治疗和 预防艾滋病毒相关的合并症，使这成为艾滋病毒/艾滋病研究中令人兴奋的时刻-但继续 要取得进展，就需要训练有素的专家科学家作出跨学科的协作努力。这个目标 建议是培养年轻科学家担任这一角色。特别是，我们将准备博士前的学生 在艾滋病毒/艾滋病研究中发挥领导作用，通过一个创新的培训计划， 专业和技术技能和知识，在一个支持性的环境，鼓励自我， 指导探索与全方位研究职业相关的学习途径。动手研究 培训将在一个突出的科学环境中进行，重点是大学的主要优势。 罗切斯特（UR）艾滋病研究中心（CFAR）和高优先领域（由NIH定义）：（1）治愈 研究，包括HIV RNA生物学和中枢神经系统（CNS）感染库;（2）结束 器官疾病和衰老，包括心血管和CNS疾病;（3）预防研究，包括 疫苗和新疗法。这个T32计划将包括专业技能的指导，结构化 研究职业发展路径，体验式学习机会和导师培训计划 旨在确保一个鼓励自主学习的支持性学习环境， 探索不同的职业选择。最后，增加了新的方案特定课程， 整体研究生课程已经精简-让更多的时间进行学科特定的培训，自我， 定向职业发展/探索和体验式学习。该计划有以下主要内容 目标：（1）通过创建独特的资源，提供优秀的跨学科研究培训 （2）提供艾滋病毒/艾滋病研究方面的杰出教学和实践教育。 这将通过纳入四个主要组成部分来实现-一个必要的核心教学课程， 具体计划的小组经验;（3）可选的选修课程，和经验，旨在鼓励 学生的探索和自主性;（4）动手论文研究;（3）通过以下方式提高培训效果： 结构化的指导。在这种情况下，学生将获得支持性的指导，这将是 通过补充的“同侪指导”和校友指导网络进一步加强， 提供一对一的咨询、指导和非正式辅导。加强教师指导 实践中，我们将采用“指导我们的导师”计划;（4）赋予学生自主权， 鼓励自我导向的学习和探索多样化的职业选择，通过利用资源， 最好的节目。 !

While the HIV/AIDS pandemic continues, the incidence of HIV infections has fallen because of the deployment of antiviral drugs and multiple prevention modalities. Recent research successes in targeting complete elimination of HIV, development of novel vaccines and therapeutics, and progress in treating and preventing HIV-associated comorbidities, makes this an exciting time in HIV/AIDS research – but continued progress will require interdisciplinary, collaborative efforts by highly trained, expert scientists. The goal of this proposal is to prepare young scientists for that role. Particularly, we will prepare predoctoral students for leadership roles in HIV/AIDS research, through an innovative training program that will provide comprehensive, professional and technical skills and knowledge, in an autonomy-supportive environment that encourages self- directed exploration of learning paths relevant to the full range of research careers. Hands-on research training will be conducted in an outstanding scientific milieu that focuses on key strengths of the University of Rochester (UR)'s Center for AIDS Research (CFAR) and high priority areas (as defined by NIH): (1) cure research, including HIV RNA Biology and the central nervous system (CNS) reservoir of infection; (2) end organ disease and aging, including cardiovascular and CNS disease; (3) prevention research, including vaccines and novel therapeutics. This T32 program will incorporate instruction in professional skills, structured research career development paths, experiential learning opportunities, and a mentor training program intended to ensure an autonomy-supportive learning environment that encourages self-directed learning and exploration of diverse career options. Finally, new program-specific courses have been added, while the overall graduate curriculum has been streamlined – to allow more time for discipline-specific training, self- directed career development/exploration and experiential learning. The program has following major objectives: (1) To provide outstanding, interdisciplinary research training enriched by unique resources created by UR's CFAR and CTSI; (2) To provide outstanding didactic and hands-on education in HIV/AIDS research. This will be achieved by incorporating four major component – a required core didactic curriculum, required program-specific group experiences; (3) optional elective courses, and experiences designed to encourage student exploration and autonomy and (4) hands-on thesis research; (3) To enhance training outcomes via structured mentoring. In this case the students will receive autonomy-supportive mentoring, which will be further enhanced by supplementary `Peer Mentoring' and through an Alumni Mentoring Network that will provide advice, guidance and informal mentoring on a one-on-one basis. To strengthen faculty mentoring practices we will employ “mentor our mentors” program; and (4) To empower student autonomy, and to encourage self-directed learning and exploration of diverse career options by leveraging resources created by UR's BEST program. !