Mechanistic Studies on video guided acupuncture imagery treatment of pain

项目总结/摘要 使用图像治疗疾病是最古老的医疗实践之一。但 治疗机制尚不清楚。最近的脑成像研究表明， 心理意象的功能本质可能是重叠的神经认知操作， 支持想象、感知和行动。针灸是一种古老的侵入性治疗方法。 以前的研究表明，无论是针灸针刺激的经验和 针灸针刺激的可视化可以引起重叠的大脑激活， 研究表明，可视化或想象针灸可以通过大脑达到治疗效果， 类似于实际针灸治疗的途径。 该应用将研究视频引导针灸的潜在大脑机制 意象治疗（VGAIT），一种新的身心治疗方式。在这种治疗中，受试者将 观看之前在自己身上进行针灸的视频，并想象这之前 治疗同时进行。在R61阶段，使用交叉设计和功能 磁共振成像（fMRI），我们将研究皮层fMRI信号的变化和休息 陈述由1）VGAIT，2）VGAIT控制条件引起的功能连接变化（受试者将 看一段视频，视频中棉花棒触碰了他们身体上的特定部位， 同时应用），3）真针，和4）假针刺给予健康 科目在R33阶段，将招募膝关节骨关节炎（OA）患者，并随机分配至 四个治疗组中的一个月：1）VGAIT，2）VGAIT对照条件，3）verum 针刺; 4）假针刺。我们将研究fMRI信号变化和静息状态 由不同条件引起的功能连接变化。 这个项目将促进新的身心干预方法的发展， 使慢性疼痛患者受益。这对老年人和残疾人特别有益 那些接受针灸和医疗护理的机会有限，但可以从自我治疗中受益的患者， 在针灸治疗后进行家庭治疗。最重要的是，A 意象针灸、真实的针灸和假针灸的比较研究将 加深我们对身心互动、意象治疗、针灸和疼痛的理解 管理

Project Summary / Abstract The use of imagery to treat illness is one of the oldest medical practices. Nevertheless, the mechanism of the treatment remains unknown. Recent brain imaging studies suggest that underlying the functional nature of mental imagery may be the overlapping neurocognitive operations that support imagination, perception, and action. Acupuncture is an ancient invasive therapeutic method. Previous studies have shown that both the experience of acupuncture needle stimulation and the visualization of acupuncture needle stimulation can provoke overlapping brain activation, which suggests that visualizing or imagining acupuncture may achieve therapeutic effects through a brain pathway similar to actual acupuncture treatment. This application will investigate the underlying brain mechanisms of video-guided acupuncture imagery treatment (VGAIT), a novel mind-body treatment modality. In this treatment, subjects will watch a video of acupuncture previously administered on their own bodies and imagine this prior treatment being concurrently applied. In the R61 phase, using a crossover design and functional magnetic resonance imaging (fMRI), we will investigate the cortical fMRI signal changes and resting state functional connectivity changes evoked by 1) VGAIT, 2) VGAIT control condition (subjects will watch a video of a cotton swab touching specific points on their bodies and imagine it being concurrently applied), 3) verum acupuncture, and 4) sham acupuncture administered on healthy subjects. In the R33 phase, knee osteoarthritis (OA) patients will be recruited and randomized to one of four treatment groups for one month: 1) VGAIT, 2) a VGAIT control condition, 3) verum acupuncture, and 4) sham acupuncture. We will investigate the fMRI signal changes and resting state functional connectivity changes evoked by the different conditions. This project will facilitate the development of new mind-body intervention methods that can directly benefit patients suffering from chronic pain. It would be especially beneficial to elderly and disabled patients who have limited access to acupuncture and medical care and could benefit from self- administered, at-home treatment following acupuncture treatment sessions. Most importantly, a comparative investigation of imagery acupuncture, real acupuncture, and sham acupuncture will deepen our understanding of mind-body interaction, imagery treatment, acupuncture, and pain management.