T Cell Costimulatory Pathways: Function and Interactions

行政核心将负责提供科学的管理和协调，财政 对此计划项目拨款的监督和行政支持，使此PPG能够继续成为 具有高度互动性和集成性的节目。行政核心将协调PPG科学小组 哈佛医学院、布里格姆和妇女医院的调查人员与达纳-法伯的会议 癌症研究所、马萨诸塞州总医院、埃默里大学和明尼苏达大学使用 视频会议和电话会议。行政核心将提供有效的 通信服务，使PPG调查人员能够共享数据、计划实验并增强他们的 合作。此外，行政核心将在#年为调查人员安排年度PPG会议。 波士顿。在行政上，该核心将协调年度进度报告和分包合同的续签 协议，并将在各机构的赠款办公室和哈佛医学院之间进行联络 学校赞助项目管理办公室。Arlene Sharpe博士作为项目负责人 调查员和她的机构哈佛医学院将负责这项申请和 描述协作研究活动。Arlene Sharpe博士将在她的支持下指导这一核心 行政助理萨拉·希尔曼和拨款管理人桑德拉·哈滕。 核心A有以下具体目标。目标1：通过以下方式为PPG提供行政支持 PPG中所有参与者之间的最佳互动；协调三个PPG项目和两个 科学核心；保持方案调查人员之间公平、有效的沟通与合作； 管理计划活动和合同协议；监督资金分配；以及提供 通过科学咨询委员会对私营部门进行监督的措施，以及目标2：维持以网络为基础的 用于数据共享的安全门户，以便于实时共享数据、规划未来实验和 协作。

The Administrative Core will be responsible for providing scientific administration and coordination, fiscal oversight and administrative support for this Program Project Grant, to enable this PPG to continue to be a highly interactive and integrated program. The Administrative Core will coordinate PPG scientific group meetings among investigators at Harvard Medical School, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Massachusetts General Hospital, Emory University and the University of Minnesota using video conferencing and telephone conference calls. The Administrative Core will provide effective communication services to enable PPG investigators to share data, plan experiments, and enhance their collaborations. In addition, the Administrative Core will arrange an annual PPG meeting for investigators in Boston. Administratively, this Core will coordinate annual progress reports and renewal of sub-contract agreements, and will liaise between the grants offices of the various institutions and the Harvard Medical School Sponsored Programs Administration office. Dr. Arlene Sharpe, as Program Project Principal investigator and her institution Harvard Medical School, will be responsible for this application and for the collaborative research activities described. Dr. Arlene Sharpe will direct this Core with the support of her administrative assistant Sarah Hillman and grants administrator Sandra Hatten. Core A has the following Specific Aims. Aim 1: To provide administrate support for the PPG by facilitating optimal interactions among all participants in the PPG; coordinating the three PPG projects with the two scientific cores; maintaining fair, effective communication and cooperation among program investigators; Managing program activities and contractual agreements; Overseeing allocation of funds; and providing a measure of oversight for PPG through the Scientific Advisory Board, and Aim 2: To maintain a web-based secure portal for data sharing to facilitate sharing of data in real time, planning of future experiments and collaboration.