Core C: Biostatistics, Bioinformatics, and Patient Registry Core

项目摘要/摘要 生物统计、生物信息学和患者登记核心提供统计和生物信息学合作 为每个孢子项目、发展研究和职业提供数据管理支持 增强项目，以及其他核心。其成员都有乳腺癌的内容知识。他们的 合作努力包括制定统计设计和分析计划、质量控制、 数据库开发、数据表格开发和处理、数据收集/摘要和录入、数据 分析和解读、手稿准备和数据存档。生物统计学核心的存在 为孢子调查人员提供了获得统计专业知识的途径，其中包括最先进的数据分析 和数据管理资源，并提供一致和兼容的数据机制 正在处理。在上一个供资期间，这些努力共出版了59份出版物。 在此续订应用程序中，生物统计、生物信息学和患者登记核心(核心C)发挥了作用 与每个孢子项目研究小组一起准备他们的项目研究计划。在整个过程中 进行这项研究，核心成员将参加项目团队会议以及较小的调查人员 会议，以确保每一位孢子调查员都能持续获得在 他们的研究工作的发展。通过这些合作活动，孢子调查人员可以 给一个具有乳腺癌内容知识的统计/生物信息学合作者团队，以确保 开发一项研究设计，能够生成数据来解决提出的问题，并确保 适用于复杂数据的统计和生物信息学分析技术的应用 在这些不同的项目中产生。这一核心补充和协助了Biosecimen和 病理学核心通过提供最先进的数据管理和与生物标本注册机构的合作。 总而言之，核心C将有助于确保梅奥诊所乳腺癌孢子的研究在 高效的、有效的和严谨的态度。

Project Summary/Abstract The Biostatistics, Bioinformatics, and Patient Registry Core provides statistical and bioinformatics collaboration and data management support for each of the SPORE projects, Developmental Research and Career Enhancement projects, and the other cores. Its members have breast cancer content knowledge. Their collaborative efforts are included the development of a statistical design and analysis plan, quality control, database development, data form development and processing, data collection/abstraction and entry, data analysis and interpretation, manuscript preparation, and data archiving. The existence of the Biostatistics Core has provided SPORE investigators access to statistical expertise which includes state of the art data analysis and data management resources as well as provides a mechanism of consistent and compatible data handling. These efforts have resulted in 59 publications over the previous funding period. In this renewal application, the Biostatistics, Bioinformatics, and Patient Registry Core (Core C) has worked with each of the SPORE project research teams in preparing their project research plans. Throughout the conduct of this research, Core members will attend Project team meeting as well as smaller investigators meetings to assure each SPORE investigator has ongoing access to the statistical expertise needed during the evolution of their research endeavor. Through these collaborative activities, SPORE investigators have access to a team of statistical/bioinformatics collaborators with breast cancer content knowledge to ensure the development of a study design that can generate data to address the questions posed as well as to ensure the application of statistical and bioinformatics analysis techniques which are appropriate for the complex data generated in these diverse projects. This core complements and assists the efforts of the Biospecimen and Pathology Core by providing state of the art data management and collaboration with biospecimen registries. In summary, Core C will help assure that research in the Mayo Clinic Breast Cancer SPORE is carried out in an efficient, effective, and rigorous manner.