DJ-1 and hexokinases

多年来，我们一直对氧化应激与DJ-1（一种罕见的隐性帕金森病病因）之间的关系感兴趣，并专注于氧化应激与线粒体定位之间的关系。在当前阶段，我们探索了DJ-1缺乏对小鼠和大鼠大脑的影响。我们发现DJ-1的缺失改变了细胞信号传导途径，从而在细胞水平上导致代谢酶变化的积累。我们目前的数据表明，改变的PTEN/Aky信号发生在细胞和体内作为DJ-1缺陷的结果。然而，在体内，Akt下游还发生了其他信号传导事件，我们随后试图确定这些与年龄相关的通路是什么。

We have been interested in the relationship between oxidative stress and DJ-1, a rare cause of recessive Parkinson's disease, for several years and have focussed the relationship between oxidative stress and mitochondrial localization. In the current period, we have explored the effects of DJ-1 deficiency in the brains of mice and rats. We find that loss of DJ-1 alters cellular signaling pathways that result, at a cellular level, in the accumulation of changes in metabolic enyzmes. Our current data suggests that altered PTEN/Aky signaling occurs both in cells and in vivo as a consequence of DJ-1 deficiency. However, in vivo there are additional signaling events that occur downstream of Akt and we are subsequently trying to identify what these age-related pathways are.