Southern California Children's Enviromental Health Center (SC-CEHC)

描述（由申请人提供） 核心的主要目标是提供一个有效的基础设施，协调和促进整个中心的活动，并促进科学整合和社区参与。Rob McConnell博士和Michael Goran博士将领导实现这些目标，分别带来环境健康和儿童肥胖/代谢功能方面的专业知识。核心的目标是确保基础，临床和公共卫生科学家和社区外展教师和工作人员之间的多学科互动，以加强世界一流的儿童健康研究和外展计划。核心将建立一个由SC-CEHC调查人员和COTC主任组成的执行委员会，以促进科学互动并协调内部/外部活动。将组织一次季度会议，更详细地介绍研究挑战和进展，并探讨三个项目和COTC之间科学互动的机会。 外部咨询委员会将每年举行会议，审查进展情况，并提供评价和咨询意见。 所有会议和讲习班都将在核心支助下举办。具体目标是： 1)协调一项研究计划，将最先进的暴露评估与创新的健康影响研究相结合，以快速了解空气污染对儿童肥胖和代谢失调的影响。核心机制将促进两个南加州大学团队之间的成熟合作，研究1）空气污染对儿童的暴露评估和健康影响，以及2）儿童肥胖和糖尿病。一个重要的资源是丰富的机构科学环境，包括互补的中心和行政基础设施，将被利用来共同主办研讨会和讲习班，并建立科学中心内外的协同作用。 2)促进研究结果的翻译/应用到预防，政策和临床决策领域，并为社区，临床医生和政策制定者提供有价值的信息。核心将为社区参与活动和儿科健康专家提供行政支持，以帮助确定科学和推广机会，以加强中心研究结果的翻译。 3)提供财务管理和报告，并协调与NIEHS和EPA的互动。核心人员将管理预算的所有方面，包括分包合同，并将协助研究项目和COTC进行采购和报销。核心委员会将编写所有报告，并与NIEHS和EPA协调。 4)培养初级研究人员的职业发展计划，使其成为儿科环境健康研究的独立贡献者。核心将协调一个强大的职业发展计划，以促进教师发展调查员的研究独立性的进展。研究人员将提供机会，对赠款申请进行模拟同行评审，审查演讲技巧，与南加州大学研究界内外的其他研究人员建立联系。职业发展活动一直是现有SCEHSC的一部分，该计划在该中心的外部审查中排名很高。此外，参加COTC活动将是一个发展非技术演示技能的机会，这将是一个宝贵的职业资产。 5)为促进儿童环境健康领域的交流、创新和卓越研究的国家网络做出重要贡献。核心、COTC和SC-CEHC领导层将参加电话会议和SC-CEHC董事年会。将寻求中心间合作的机会。此外，SC-CEHC研究人员将参加全国电话会议，包括环境公共卫生网络NIEHS计划和其他团体的电话会议，以介绍SC-CEHC关于空气污染，肥胖和代谢后果的最新研究结果。

DESCRIPTION (provided by applicant) The primary goal of the Core is to provide an efficient infrastructure coordinating and facilitatin activities across the Center and to promote scientific integration and community engagement. Drs. Rob McConnell and Michael Goran will provide leadership to achieve these goals, bringing expertise in environmental health and childhood obesity/metabolic function, respectively. The goal of the Core is to ensure multidisciplinary interactions among basic, clinical, and public health scientists and community outreach faculty and staff to enhance a world-class research and outreach program in children's health. The Core will establish an Executive Committee of SC-CEHC investigators and the COTC Director to foster scientific interaction and coordinate internal/external activities. A quarterly meeting will be organized to present research challenges and progress in more detail and to explore opportunities for scientific interaction across the three Projects and the COTC. An External Advisory Committee will meet annually to review progress and to provide evaluation and advice. All meetings and workshops will be organized with Core support. Specific Aims are to: 1) Coordinate a program of research that integrates state-of-the-art exposure assessment with innovative health effects research to achieve rapid advances in understanding the impact of air pollution on childhood obesity and metabolic dysregulation. The Core mechanisms will facilitate maturing collaboration between two USC teams conducting research on 1) exposure assessment and health effects of air pollution in children and 2) childhood obesity and diabetes. An important resource is the rich institutional scientific environment including complementary centers and an administrative infrastructure that will be leveraged to co-sponsor seminars and workshops and build scientific synergy within and outside the Center. 2) Facilitate the translation/application of research findings to prevention, policy, and clinical decision making arenas and provide valuable information to communities, clinicians and policymakers. The Core will provide administrative support to community engagement activities and to the Pediatric Health Specialist to help identify scientific and outreach opportunities for enhancing translation of Center research findings. 3) Provide fiscal management and reporting and coordinate interactions with NIEHS and EPA. The Core will manage all aspects of the budget including subcontracts and will assist the research projects and COTC with purchasing and reimbursements. The Core will prepare all reports and coordinate with NIEHS and EPA. 4) Foster the career development program of junior investigators into independent contributors to pediatric environmental health research. The Core will coordinate a robust career development program to promote the progress of the faculty development investigator to research independence. The investigators will provide opportunities for mock peer review of grant applications, review of presentation skills, networking with other investigators within the USC research community and beyond. Career development activities have been part of the existing SCEHSC, a program which ranked highly in that center's external review. In addition, participation in COTC activities will be an opportunity to develop skills in non-technical presentations that will be a valuable career asset. 5) Make important contributions to national networks that foster communication, innovation, and research excellence in the area of children's environmental health. The Core, COTC and SC-CEHC leadership will participate in conference calls and the annual meetings of SC-CEHC directors. Opportunities for inter-Center collaboration will be sought. In addition, SC-CEHC investigators will participate in national conference calls including those of the NIEHS Programs in Environmental Public Health Network, and of other groups, to present the SC-CEHC's most recent research findings on air pollution, obesity and metabolic consequences.