Project 3

项目3

• 批准号: 10252832
• 负责人: ROB S MCCONNELL
• 金额: $ 37.53万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-19 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10252832
• 关键词: Address; Adolescence; Adolescent and Young Adult; Adopted; Adverse effects; Aerosols; Affect; Age; Age-Years; Behavior; Cartoons; Characteristics; Cigarette; Cigarette Smoker; Clip; Complement; Curiosities; Data; Dependence; Development; Devices; Electronic cigarette; Ethnic Origin; Experimental Designs; Exposure to; Health; Image; Individual; Infrastructure; Link; Marketing; Methods; Mission; Modeling; Names; Nicotine; Nicotine Dependence; Outcome; Pattern; Peptide Initiation Factors; Policies; Population; Population Heterogeneity; Positioning Attribute; Prospective Studies; Public Health; Questionnaires; Race; Regulation; Reporting; Research; Resources; Risk; Risk Factors; Salvelinus; Sampling; Sex Orientation; Smell Perception; Smoke; Smoker; Smoking Status; Social Interaction; Socioeconomic Status; Surveys; Taste Perception; Testing; Tobacco; Tobacco use; Variant; Visual; Vulnerable Populations; Youth; addiction; cigarette smoking; cohort; comparative; computerized; e-cigarette cessation; early adolescence; electronic cigarette use; electronic cigarette user; electronic liquid; emerging adulthood; follow-up; innovation; interest; never smoker; nicotine use; non-smoker; prospective; response; sex; smoking cessation; social media; success; sweet taste perception; tobacco advertising; tobacco regulatory science; vaping; young adult

ABSTRACT: PROJECT 3 (P3) Background: Electronic (e)-cigarettes are the most commonly used tobacco product in adolescents and young adults. E-cigarette use is associated with subsequent cigarette initiation in this population. E-cigarette product diversity (i.e., product characteristics and associated marketing strategies) could be a target for FDA product standards and marketing restrictions to reduce the adverse impact of e-cigarettes in young people. Yet, there has been little evidence on this topic. P3 will test hypothesized e-cigarette product characteristics and marketing strategies that may attract never-smokers and put them at risk for tobacco product use but do not affect the likelihood that young smokers will adopt and switch to e-cigarettes. Such data will inform regulatory policies that meet FDA’s mission to ‘protect the population as a whole.’ Example hypothesized product features that may disproportionately attract never smokers (vs. smokers) include sweet flavors (vs. tobacco or other flavors), de- vices and e-liquid compositions used to generate large aerosol clouds for “vape tricks’ (vs. devices that look and feel like cigarettes), and youth-oriented marketing strategies for e-liquid naming, such as “Kustard Killer,” and packaging with (vs. without) cartoon images. Method: P3 will test these hypotheses in a large Center-wide USC- TCORS cohort (N=6400) overseen by the Population Core. Rich longitudinally collected data, including up to 8 years of cumulative follow-up will span critical developmental windows from 14-24 years of age, during which lifelong tobacco use patterns have historically been established. Aim 1. To investigate the association of: 1a) e- cigarette product diversity with appeal and interest in e-cigarettes, using an innovative within-subject experi- mental design including exposure to still images of products and marketing, and GIFs of vape clouds embedded in computerized survey interface (developed with assistance from the Administrative Core and other projects), 1b) e-cigarette interest with subsequent e-cigarette initiation, and 1c) product marketing exposure via various channels with e-cigarette initiation. Aim 2. To evaluate the association of 2a) e-cigarette initiation with tobacco product use outcomes (i.e., e-cigarette and cigarette progression to regular use, dependence, and cessation), and 2b) e-cigarette product characteristics and marketing exposures (via several channels) with tobacco prod- uct use outcomes. Aim 3. To evaluate whether associations of product characteristics and marketing with out- comes observed in Aims 1 and 2 differ between baseline never-smokers and smokers. Integration with “Inter- sections of Products with Populations” theme: P3 will study a variety of domains of e-cigarette product di- versity that overlap with and complement domains studied by the other USC-TCORS projects. P3 uniquely addresses population diversity in the Center by comparing current smokers while they are still young (age <24) with never-smokers. P3 will also examine differential associations by sex, race/ethnicity, sexual orientation, and socioeconomic status. FDA Scientific domains addressed: Addiction, Behavior, and Marketing.

摘要：项目3（P3） 背景：电子（e） - 果岭是青少年和年轻的最常用的烟草产品 成年人。电子烟的使用与该人群中随后的香烟开始有关。电子烟产品 多样性（即产品特征和相关营销策略）可能是FDA产品的目标 标准和营销限制，以减少电子烟对年轻人的不利影响。但是，那里 关于这个话题的证据很少。 P3将测试假设的电子烟产品特征和营销 可能会吸引永不吸烟并将其冒着烟草产品使用的策略，但不会影响 年轻吸烟者会采用并改用电子烟的可能性。这些数据将告知监管政策 符合FDA的使命，即“保护整个人口”。示例假设的产品功能可能 不成比例地吸引从不吸烟者（与吸烟者）包括甜味（烟草或其他口味），DE- 用于生成“ vape tricks”的大型气溶胶云的恶习和电子液体组成（与外观和的设备相比 感觉像香烟），以及以青年为导向的电子液体命名的营销策略，例如“ Kustard Killer”和 包装（vs.没有）卡通图像。方法：P3将在大型的中央USC-中检验这些假设 TCORS队列（n = 6400）由人口核心监督。丰富的纵向收集数据，包括多达8个 多年的累积随访将跨越14-24岁的关键发展窗口，在此期间 历史上已经建立了终生的烟草使用模式。目的1。调查：1a）e-的关联 香烟产品多样性具有外观和对电子烟的兴趣，利用受试者内部体验 - 心理设计包括接触产品和营销的静止图像，以及嵌入的vape云的GIF 在计算机调查接口（在行政核心和其他项目的帮助下开发）中， 1b）电子烟的兴趣，随后的电子烟开始，1C）通过各种 带有电子烟计划的渠道。目标2。评估2A）电子烟计划与烟草的关联 产品使用结果（即电子烟和香烟的定期使用，依赖和戒烟）， 和2b）电子烟产品特征和营销暴露（通过多个渠道）带有烟草产品 UCT使用结果。目的3。评估产品特征和营销的关联是否与 在基线从未吸烟者和吸烟者之间观察到的目标1和2不同。与“ 主题：P3将研究电子烟产品的各种领域di- 与其他USC-TCORS项目重叠和补充域研究的版本。 P3独特 通过比较当前的吸烟者还很年轻（年龄<24）来解决中心的人口多样性 与永不吸烟的人。 P3还将通过性别，种族/种族，性取向以及 社会经济地位。 FDA科学领域涉及：成瘾，行为和营销。