甲基苯丙胺使用和艾滋病毒疾病中血脑屏障损伤的生物标志物-猫眼课题宝

甲基苯丙胺使用和艾滋病毒疾病中血脑屏障损伤的生物标志物

批准号：

9249011

负责人：

Jennifer E Iudicello

金额：

$20.52万

依托单位：

UNIVERSITY OF CALIFORNIA, SAN DIEGO

依托单位国家：

美国

项目类别：

财政年份：

2014

资助国家：

美国

项目状态：

已结题

起止时间：

2014-04-01 至 2019-03-31

来源：

https://reporter.nih.gov/project-details/9249011

关键词：

Acquired Immunodeficiency Syndrome Affect Area Basement membrane Biological Biological Markers Blood Blood - brain barrier anatomy Brain Cell Adhesion Molecules Clinical Clinical Research Collaborations Communicable Diseases Data Collection Development Diagnosis Disease Endothelial Cells Fostering Foundations Functional disorder Future Goals Grant HIV Health Immune system Individual Influentials Injury Investigation Knowledge Laboratories Lead Link Measures Mediating Membrane Proteins Mentored Patient-Oriented Research Career Development Award Mentors Methamphetamine Methamphetamine dependence Monitor Nervous System Trauma Neurobiology Neurocognitive Neurocognitive Deficit Neuronal Injury Neuropsychology Neurosciences Outcome Pathogenesis Pathogenicity Persons Prevalence Process Proteins Public Health Reporting Research Research Infrastructure Research Methodology Research Personnel Resources Risk Factors Role Science Serum Albumin Services Stem cells Structure Substance abuse problem Tight Junctions Training Universities Vascular Diseases Vascular System Virus Work addiction analytical method antiretroviral therapy assay development base biomarker panel career central nervous system injury drug development effective therapy experience experimental study functional decline functional disability functional outcomes immune activation improved innovation insight methamphetamine effect methamphetamine use multidisciplinary neuroAIDS neurobehavioral neurovascular neurovascular injury outcome forecast patient oriented patient oriented research programs public health relevance skills specific biomarkers statistics tool translational research program

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中文摘要

翻译

Jennifer Iudicello博士申请K23的目的是提供有针对性的培训和指导甲基苯丙胺(冰毒)成瘾和HIV疾病的神经生物学方面成瘾和神经艾滋病的神经认知和功能后果的学术基础作为一名独立的、以患者为中心的跨学科研究人员，她的长期目标得到了实现。建议数培训、知识和研究经验将促进她发展成为一名独立的调查员能够将实验室神经生物学发现与其临床表现和现实世界的影响联系起来在患有冰毒成瘾和艾滋病毒疾病的人中。这项工作意义重大

英文摘要

The purpose of Dr. Jennifer Iudicello’s K23 application is to provide focused training and mentoring in the neurobiological aspects of methamphetamine (METH) addiction and HIV disease that builds on her strong academic foundation in the neurocognitive and functional consequences of addictions and neuroAIDS in service of her long-term goals as an independent, transdisciplinary patient-oriented investigator. The proposed training, knowledge, and research experience will promote her development into an independent investigator capable of bridging laboratory neurobiological discoveries with their clinical expression and real-world impact among persons living with METH addiction and HIV disease. This work is of considerable

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