Integrative Health Sciences Facility Core

项目摘要-综合健康科学设施 综合健康科学基金(IHSF)的总体目标是鼓励、支持和加强 与环境健康科学相关的临床和翻译研究。此外，通过我们的状态- 我们为研究人员提供先进的成像设备，以评估和分析效果 环境空气污染物对肺部结构的影响。这项技术可以应用于啮齿动物等小动物， 大型动物，如猪和人类，促进与环境有关的基本发现的翻译 暴露在人类身上。为了实现这一目标，IHSF将：1)提供进行临床研究的基础设施 和与环境健康科学有关的翻译研究；2)确保临床和翻译 安全地进行研究，并对受试者保密；3)为 培训对环境健康科学感兴趣的年轻临床/翻译研究人员；和4) 支持EHSRC研究人员利用临床和翻译科学研究所(ICTS)和 促进新的多学科研究合作。设施服务主要集中在三个主要领域： 研究课题的招募、评估和评估。为了支持这些领域，我们进行了一项研究 学科招募和互动部分，成像部分，心肺生理学 组件和生物采样组件。IHSF促进了爱荷华大学资源的使用， 特别是临床研究单位、心血管人体生理学实验室、 核心分析实验室、ICTS研究安全办公室和临床支气管镜检查套件。在未来 我们将支持基础设施，以加强不同研究人员之间的合作(来自 公共卫生学院、医学学院、工程学院、药学学院和文理学院)拥有共同的 对环境和遗传影响的、与炎症相关的肺部病理感兴趣，包括 慢性阻塞性肺病、哮喘、囊性纤维化、职业性肺部疾病和癌症。我们正在开发一种信息学 在整个爱荷华大学医疗网络中协调肺部成像方案的服务，以便我们 可以迅速扩展我们的图像数据库及其对研究的效用。这一独特的数据集将提供 测试与环境暴露对环境的贡献有关的假设的机会 肺部疾病的发展。这项研究使用成像来定义有意义的功能和结构 将环境和遗传因素与肺部疾病联系起来的表型表达与 环境健康科学研究中心的目标。综合健康科学机构 是促进临床研究和转化性研究在 EHSRC。

PROJECT SUMMARY – INTEGRATIVE HEALTH SCIENCES FACILITY The overall goal of the Integrative Health Sciences Facility (IHSF) is to encourage, support and enhance clinical and translational studies relevant to environmental health sciences. In addition, through our state-of- the-art imaging facility we provide investigators with cutting edge technology to evaluate and analyze effects of ambient air pollutants on lung structures. This technology can be applied to small animals such as rodents, large animals such as pigs, and humans, promoting translation of basic discoveries related to environmental exposures to humans. To accomplish this goal, the IHSF will, 1) Provide the infrastructure to carry out clinical and translational studies relevant to environmental health sciences; 2) Ensure that clinical and translational studies are carried out safely and that subject confidentially is maintained; 3) Provide the infrastructure for training of young clinical/translational investigators with an interest in environmental health sciences; and 4) Support EHSRC investigators who utilize the Institute for Clinical and Translational Science (ICTS) and promote new multidisciplinary research collaborations. The facility services are focused on three main areas: recruitment, evaluation and assessment of research subjects. To support these areas, we have a Research Subject Recruitment and Interactions Component, Imaging Component, Cardiopulmonary Physiology Component, and Biologic Sampling Component. The IHSF facilitates the use of University of Iowa resources, specifically the ICTS Clinical Research Unit, the Cardiovascular Human Physiology Laboratory, the ICTS Core Analytical Laboratory, the ICTS Research Safety Office, and the Clinical Bronchoscopy Suite. In future initiatives we will support the infrastructure to enhance collaboration between diverse researchers (from the Colleges of Public Health, Medicine, Engineering, Pharmacy, and Liberal Arts and Sciences) with a common interest in environmentally and genetically influenced, inflammatory-associated lung pathologies, including COPD, asthma, cystic fibrosis, occupational lung diseases, and cancer. We are developing an informatics service to harmonize lung-imaging protocols throughout the University of Iowa Healthcare Network so that we can rapidly expand our imaging database and its utility for research studies. This unique dataset will provide the opportunity to test hypotheses related to the contributions that environmental exposures have to the development of lung diseases. This research using imaging to define meaningful functional and structural phenotypic expressions linking environmental and genetic factors to lung disease is highly relevant to the goals of the Environmental Health Sciences Research Center. The Integrative Health Sciences Facility represents a critical resource to facilitate the conduct of clinical and translational research studies within the EHSRC.