Predictive Blood and Cerebrospinal Fluid Metabolomic Markers in Alzheimers Disease

阿尔茨海默病的脆弱性和恢复力的代谢基础尚不清楚。在这些分析中，我们希望通过检查脑组织中约800种代谢物的浓度是否与大脑中AD病理的严重程度和AD症状的表达有关来解决这个问题。如果我们确定了这些代谢物，我们希望测试这些代谢物是否也是认知正常的老年人患AD风险较高(或较低)的预测因素。本研究的最终目的是确定与AD生物学相关的生物标志物，并了解介导AD病理风险/弹性的确切分子机制。

The metabolic basis of vulnerability and resilience to AD pathology remains unknown. In these analyses, we hope to address this question by examining whether brain tissue concentrations of approximately 800 metabolites are associated with severity of AD pathology in the brain and the expression of AD symptoms. If we identify such metabolites, we hope to then test whether these metabolites are also predictors of greater (or lower) risk of AD in cognitively normal older individuals. The ultimate goal of this study is to identify biologically relevant biomarkers of AD and to understand the precise molecular mechanisms mediating risk/resilience to AD pathology.