Head and Neck Cancer SPORE

描述(由申请者提供)：匹兹堡大学建议继续在头颈癌方面进行卓越研究(孢子)的专业计划。头颈部孢子的总体目标是改善头颈部癌症的预防和治疗以及甲状腺癌的检测和治疗(在这次更新中是新的)。孢子计划包括四个翻译研究项目，三个专注于头颈部鳞状细胞癌(HNSCC)，一个专注于甲状腺癌，两个研究核心，一个行政核心，一个发展研究计划和一个职业发展计划。孢子将使用跨学科的方法，通过开展由基础、应用和临床科学的研究人员共同领导的项目来实现其目标。人头的长期目标 和颈部孢子是根据转译研究项目的研究结果进行临床研究，这些研究将作为改善被诊断为头颈癌的个人结果的基础。这四个主要项目包括：(1)头颈癌的化学预防；(2)用于头颈癌治疗的STAT3诱骗的优化；(3)检查点受体靶向，以增强西妥昔单抗对HNSCC的疗效；以及(4)分子引导的甲状腺结节和癌症的风险分层。这三个核心将密切互动，协助主要研究项目、发展研究项目和职业发展调查人员开展转化型头颈部癌症研究。研究核心包括：(A)组织学/组织学和(B)信息学、生物统计学和生物信息学。行政核心将征求内部和外部科学咨询委员会的反馈，并为孢子计划提供科学、监管和财政监督。头颈部孢子调查人员将共同努力，协同实现该计划的目标，并将继续与其他机构的其他头颈部和甲状腺孢子调查人员以及合作小组密切互动，以改善头颈部癌症患者的预后。

DESCRIPTION (provided by applicant): The University of Pittsburgh proposes to continue a Specialized Program of Research Excellence (SPORE) in Head and Neck Cancer. The overall goals of the Head and Neck SPORE are to improve the prevention and treatment of head and neck cancer as well as the detection and treatment of thyroid cancer (new in this renewal). The SPORE program consists of four translational research projects, 3 focused on head and neck squamous cell carcinoma (HNSCC) and one focused on thyroid cancer, two research cores, an administrative core, a developmental research program and a career development program. The SPORE will use an interdisciplinary approach to meet its objectives by carrying out projects jointly led by investigators in basic, applied and clinical science. The long-term goal of the Head and Neck SPORE is to conduct clinical studies based on research results from the translational research projects that will serve as the basis for improving the outcome of individuals diagnosed with head and neck cancers. The four main projects include: (1) Chemoprevention of Head and Neck Cancer; (2) Optimization of STAT3 Decoy Delivery for Head and Neck Cancer Treatment; (3) Checkpoint Receptor Targeting to Enhance Cetuximab Efficacy Against HNSCC; and (4) Molecular-Guided Risk Stratification of Thyroid Nodules and Cancer. The three cores will interact closely to assist the main research projects, developmental research projects and career development investigators in carrying out translational head and neck cancer research. The research cores include: (a) Histology/Tissue and (b) Informatics, Biostatistics and Bioinformatics. The Administrative Core will solicit feedback from the Internal and External Scientific Advisory Boards and provide scientific, regulatory and fiscal oversight for the SPORE program. The Head and Neck SPORE investigators will work together to synergistically achieve the goals of the program and will also continue to interact closely with investigators from other Head and Neck and Thyroid SPOREs at other institutions, as well as the cooperative groups, to improve the outcome of patients with cancers of the head and neck.