Assessing vigilance with resting-state fMRI

项目摘要 静息状态功能磁共振成像(Rsfmri)是无创检查的主要方法。 人脑功能连通性和静息状态活动的特征。在之前的工作中 我们发现，rsfMRI的连通性和信号方差测量可以显著改变 目标的警戒状态。除非考虑到警觉上的这些差异，否则 连接强度和信号变化可能被解释为与疾病相关的变化。目前， 脑电(EEG)测量大脑活动被认为是 对警觉的评估。然而，它们在rsfmri研究中的应用受到技术挑战和 同时进行rsfMRI和EEG测量所涉及的后勤工作。一种替代方法，它确实 不需要获取脑电数据将极大地便利在广泛的范围内评估警觉 RsfMRI研究。该项目的目标是开发和验证一种基于rsfMRI的警戒措施。这个 这项研究的目的是(1)开发和优化基于rsfmri的警戒级别和波动的测量。 以及(2)在精神分裂症患者的样本中对该方法的有效性进行初步测试。

Project Summary Resting-state functional magnetic resonance imaging (rsfMRI) is a leading method for the non-invasive characterization of the functional connectivity and resting-state activity of the human brain. In our prior work we have found that rsfMRI measures of connectivity and signal variance can be significantly altered by the subject's vigilance state. Unless these differences in vigilance are taken into account, differences in connectivity strength and signal variance might be interpreted as a disease-related changes. Currently, electroencephalographic (EEG) measures of brain activity are considered the standard approach for the assessment of vigilance. However, their use in rsfMRI studies is limited due to the technical challenges and logistics involved in obtaining simultaneous rsfMRI and EEG measurements. An alternative approach that does not require the acquisition of EEG data would greatly facilitate the assessment of vigilance in a wide range of rsfMRI studies. The goal of this project is to develop and validate an rsfMRI-based measure of vigilance. The aims of the study are to (1) Develop and optimize rsfMRI-based measures of vigilance levels and fluctuations and (2) Perform a preliminary test of the efficacy of the method in a sample of subjects with schizophrenia.