Metabolism Core

项目总结 通过这项Cobre申请，我们寻求建立儿童肥胖预防中心。目标是 新陈代谢的核心C是为代谢研究提供支持，包括运动研究和生物学研究 样本分析，针对中心的项目。人们认识到，次优的营养和锻炼是 肥胖发展中的重要因素，这些因素的改善对于逆转肥胖症至关重要 肥胖症及其相应的新陈代谢障碍。然而，这一改进的结构是 有争议的，例如，可以单独锻炼，而不改变体重，改善肥胖相关的代谢 骚乱。代谢核心(MC)包括一个用于运动对照研究的体力活动设施 和底物代谢，一个特殊的程序/测试设备和一个分析实验室，用于分析生物 样本。MC将在新陈代谢研究方面协助和指导初级调查人员， 包括使用稳定的同位素示踪技术来测量代谢率，并将有助于未来的设计 肥胖症新陈代谢的资助研究。在初级调查员初级项目中，重点将放在 瘦子和肥胖儿童以及肥胖孕妇对营养干预(益生菌、 氨基酸或蛋白质)。干预对胰岛素敏感性、脂肪氧化、全身蛋白的影响 将确定周转(合成和分解)以及血浆和肝脏脂肪含量/肝脏脂肪变性。 MC还将教育和支持Cobre初级调查人员进行物理测量 社区/实地研究中的活动和生物反应。因此，核心增加了授予的唯一性 在这项研究中，肥胖症的实验室研究和社区研究以一种转换的方式联系起来。新陈代谢 CORE对于修订后的应用程序来说是新的。

PROJECT SUMMARY Through this COBRE application, we seek to establish the Center for Childhood Obesity Prevention. The goal of the Metabolism Core C is to provide support for metabolic studies, including exercise studies and biological sample analyses, for projects in the Center. It is recognized that suboptimal nutrition and exercise are important factors in the development of obesity, and that improvement of these factors are vital for the reversal of obesity and its corresponding disturbances in metabolism. The structure of this improvement is however debated, e.g., can exercise alone, without changes in bodyweight, improve obesity related metabolic disturbances. The Metabolism Core (MC) includes a physical activity facility for controlled studies of exercise and substrate metabolism, a special procedure/testing facility, and an analytical lab for analyses of biological samples. The MC will assist and mentor the junior investigators in the performance of metabolic studies, including use of stable isotope tracer techniques to measure metabolic rates, and will assist in design of future fundable studies of metabolism in obesity. Among the primary junior investigator projects, focus will be on the response of lean and obese children and also obese pregnant women, to nutritional interventions (probiotics, amino acids or protein). The effects of interventions on insulin sensitivity, fat oxidation, whole body protein turnover (synthesis and breakdown), and plasma and liver lipid content/hepatic steatosis, will be determined. The MC will also serve to educate and support the COBRE junior investigators in measurement of physical activity and biological responses in community/field studies. Thus, the core adds to the uniqueness of the grant in that lab studies and community studies of obesity are bridged in a translational manner. The Metabolism Core is NEW to the revised application.