TUSM/T-NEMC CENTER FOR NEUROSCIENCE RESEARCH

描述（由申请人提供）：此更新申请要求支持塔夫茨神经科学研究中心（CNR），这是一个NINDS资助的中心，为塔夫茨神经科学社区提供研究核心服务。我们的神经科学小组由50多个研究实验室组成，其中包括12名NINDS资助的研究人员，在塔夫茨大学和塔夫茨医学中心的11个部门。目前，塔夫茨大学有49个NIH神经科学赠款（今年的总费用约为1200万美元），其中大部分利用了NINDS资助的CNR提供的核心服务。塔夫茨神经科学计划非常关注突触神经生物学，并强调神经系统疾病，研究人员在与阿尔茨海默氏症，帕金森氏症，ALS，自闭症谱系障碍，癫痫，抑郁症，焦虑症，脊髓损伤，脑癌和睡眠障碍相关的领域进行研究。CNR核心对塔夫茨神经科学研究产生了重大影响，为生物成像、基因表达谱、电生理学和行为测试提供了培训和先进设备。仅在此资助期间，约80%的塔夫茨神经科学研究实验室使用CNR核心设施，在过去4年中在核心进行的研究已经产生了至少92篇出版物，其中许多描述了塔夫茨研究人员的合作研究。令人印象深刻的是，在这个资助周期中，塔夫茨大学的研究人员获得了75笔包含CNR核心使用初步结果的赠款，其中大部分是神经科学领域的研究。负担得起的CNR研究服务提供了一个有吸引力的补充启动包6新的初级教师在塔夫茨神经科学系聘请在此资助期间，大大加快了他们的研究计划。塔夫茨大学在过去的7年里已经投资了超过1800万美元用于支持神经科学。这些资金已被用于翻新神经科学系的空间，包括CNR核心，并在过去的4年里雇用了一个椅子和7个额外的系教师。塔夫茨大学在过去的两个赠款周期中慷慨地支持CNR活动;它将在下一个周期中增加一倍以上的支持，为CNR试点赠款计划和其他中心活动提供总计50万美元。

DESCRIPTION (provided by applicant): This renewal application requests support for the Tufts Center for Neuroscience Research (CNR), a NINDS-funded center that provides research core services to the Tufts neuroscience community. Our neuroscience group consists of more than 50 research laboratories, including 12 NINDS-funded investigators, in 11 Departments of Tufts University and Tufts Medical Center. At present, there are 49 NIH neuroscience grants at Tufts (~$12M in total costs this year), and the majority of them utilize core services provided by the NINDS-funded CNR. The Tufts Neuroscience Program has a strong focus in synapse neurobiology and an emphasis on neurological disease, with investigators conducting research in areas related to Alzheimer's, Parkinson's, ALS, Autism-spectrum disorders, epilepsy, depression, anxiety, spinal injury, brain cancers and sleep disorders. The CNR Cores have significant impact on Tufts neuroscience research, providing training and ready access to advanced equipment for biological imaging, gene expression profiling, electrophysiology and behavioral testing. During this funding period alone, ~80% of Tufts neuroscience research labs used CNR core facilities, and research conducted in the cores during the last 4 years has resulted in at least 92 publications, many of them describing collaborative studies by Tufts investigators. Impressively, 75 grants containing preliminary results from CNR core use were awarded to Tufts investigators during this funding cycle, the majority in the area of neuroscience. The affordable CNR research services have provided an attractive supplement to the start-up packages of 6 new junior faculty hired in the Tufts Neuroscience Department during this funding period, greatly accelerating their research programs. Tufts University has invested more than $18M in support of neuroscience in the last 7 years. These funds have been used to renovate neuroscience department space, including CNR cores, and to hire a chair and 7 additional department faculty in the last 4 years. Tufts University has generously supported CNR activities in the last 2 grant cycles; it will more than double its support in the next cycle, providing a total of $500,000 for the CNR Pilot Grant Program and other center activities.