Robust person-centered longitudinal data analysis for clinical alcohol research

描述（由申请人提供）：本申请拟开发以人为本的纵向统计模型的三个关键组成部分：(a)一项全面的模拟研究，旨在了解用于推导基于群体的轨迹的各种模型的细微表现，(b)一个交叉验证程序，旨在增强这些模型在对照、临床试验和有效性试验中使用时的信心（在复制和一致性方面），以及(c)通过开发一个用户友好的、可免费获得的带有图形用户界面的软件来促进这些先进技术的传播。

DESCRIPTION (provided by applicant): This application proposes to develop three key components in person-centered longitudinal statistical models: (a) a comprehensive simulation study designed to understand the nuanced performance of a wide range of models used to derive group based trajectories, (b) a cross-validation procedure designed to bolster the confidence (in terms of replication and consistency) of these models when employed in controlled, clinical trials and effectiveness trials, and (c) to promote dissemination of these advanced techniques by developing a user- friendly, freely available software with a graphical-user interface.