Vermont Center on Behavior and Health

描述(由申请人提供)：这是一份修订后的申请，要求在佛蒙特州大学(UVM)建立行为与健康生物医学研究卓越中心(Cobre)。拟议的中心将调查个人行为与慢性病和过早死亡风险之间的关系。在美国，每年40%的过早死亡是由不健康的个人行为(如滥用药物、缺乏运动)造成的，并大幅增加了医疗成本和健康差距。迫切需要：(A)更科学地了解导致这些危险行为易受伤害的机制；(B)采取更有效的干预措施，促进行为改变。我们将从行为经济学的概念框架来应对这些挑战。这项工作将涉及以下关键的跨学科合作：(A)在密歇根州立大学内的多个部门和学院之间进行合作；(B)与佛蒙特州的主要社区医疗保健领导者进行合作；以及(C)与其他大学，包括来自IDEA州的两所大学(布朗大学和肯塔基大学)进行合作。这项建议的具体目标是：目标1：建立必要的核心，以发展和维持一个充满活力的跨学科卓越研究中心。这一目标的目标包括：(A)建立一个行政核心，提供领导、组织结构、智力基础设施、指导计划、财政管理和战略规划，为科布雷资助以外的财政支助提供支持；(B)行为经济学和干预科学核心，支持干预措施的制定和评估、成本效益的计量模型、与健康有关的决策及其神经生物学基础的研究；以及(C)协作、传播和教育核心，以促进这些关键任务。目标2：支持优秀初级教员项目主任的选拔和职业发展，他们将成为中心的核心。PDS及其研究主题如下：(1)Robert Althoff，医学博士，博士，儿童功能障碍、成人精神病理学和代谢紊乱的共同机制；(2)Diann Gaalema，博士，激励措施，改善低收入患者的心脏康复参与；(3)Julie Phillips，医学博士，激励措施，针对超重/肥胖低收入妇女的妊娠体重增加；(4)Kim Dittus，医学博士，博士，超重乳腺癌幸存者减肥成功的预测因素；(5)Brian Sprague，博士，行为，慢性病，和导管原位癌后生活质量。拟建的中心将汇集一个由资深科学家、有前途的初级研究人员以及杰出的顾问和合作者组成的跨学科小组，密切合作，在对美国公共卫生至关重要的临床研究领域建立一个卓越的中心。

DESCRIPTION (provided by applicant): This is a revised application for support to establish a Center for Biomedical Research Excellence (COBRE) in Behavior and Health at the University of Vermont (UVM). The proposed center will investigate relationships between personal behaviors and risk for chronic disease and premature death. Unhealthy personal behaviors (e.g., substance abuse, physical inactivity) account for 40% of premature deaths in the U.S. annually and substantially increase healthcare costs and health disparities. There is a tremendous need for (a) greater scientific understanding of the mechanisms underpinning vulnerability to these risk behaviors and (b) more effective interventions to promote behavior change. We will approach these challenges from a behavioral economics conceptual framework. This effort will involve key interdisciplinary collaborations (a) across multiple departments and colleges within UVM, (b) with key Vermont community healthcare leaders, and (c) with other universities, including two from IDeA states (Brown University and University of Kentucky). Specific Aims of this proposal are: Aim 1: Establish the cores necessary to develop and sustain a vibrant interdisciplinary center of research excellence. Goals of this aim include developing (a) an Administrative Core that provides leadership, organizational structure, intellectual infrastructure, a mentoring plan, fiscal management, and strategic planning for fiscal support beyond COBRE funding; (b) a Behavioral Economics and Intervention Sciences Core that supports intervention development and evaluation, econometric modeling of cost effectiveness, and the study of health-related decision making and its neurobiological underpinnings, and (c) a Collaboration, Dissemination, and Education Core to facilitate those key missions. Aim 2: Support the selection and career development of excellent junior\faculty Project Directors (PDs) who will become the nucleus of the center. The PDs and their research topics are: (1) Robert Althoff, MD, PhD, Shared Mechanisms in Child Dysregulation, Adult Psychopathology, and Metabolic Disorders; (2) Diann Gaalema, PhD, Incentives to Improve Cardiac Rehabilitation Participation in Low-income Patients; (3) Julie Phillips, MD, Incentives Targeting Gestational Weight Gain in Overweight/Obese Low-income Women; (4) Kim Dittus, MD, PhD, Predictors of Weight Loss Success in Overweight Breast Cancer Survivors; (5) Brian Sprague, PhD, Behaviors, Chronic Disease, and Quality of Life After Ductal Carcinoma In Situ. The proposed center will bring together an interdisciplinary group of accomplished senior scientists, promising junior investigators, and distinguished advisors and collaborators to work closely together to establish a center of excellence in an area of clinical research that is vitall important to the U.S. public health.