Vermont Center on Behavior and Health

描述（由申请人提供）：这是一份修订后的申请，旨在支持在佛蒙特大学（UVM）建立行为与健康生物医学研究卓越中心（COBRE）。拟建的中心将调查个人行为与慢性病和过早死亡风险之间的关系。不健康的个人行为（例如，滥用药物，缺乏体育锻炼）占美国每年过早死亡的40%，并大大增加了医疗成本和健康差距。迫切需要(a)对这些风险行为脆弱性的机制有更深入的科学理解，以及(b)更有效的干预措施来促进行为改变。我们将从行为经济学的概念框架来处理这些挑战。这项工作将涉及关键的跨学科合作(a) UVM内多个部门和学院之间的合作，(b)与佛蒙特州主要社区医疗保健领导者的合作，以及(c)与其他大学的合作，包括来自IDeA州的两所大学（布朗大学和肯塔基大学）。该提案的具体目标是：目标1：建立必要的核心，以发展和维持一个充满活力的跨学科卓越研究中心。这一目标的目标包括发展(a)一个行政核心，提供领导力、组织结构、智力基础设施、指导计划、财政管理和战略规划，以提供COBRE资金以外的财政支持；(b)行为经济学和干预科学核心，支持干预发展和评估，成本效益的计量经济学模型，以及健康相关决策及其神经生物学基础的研究；(c)协作、传播和教育核心，以促进这些关键任务。目标2：支持优秀的初级教师项目主任（pd）的选择和职业发展，他们将成为中心的核心。pd及其研究课题为：(1)Robert Althoff，医学博士，儿童失调、成人精神病理学和代谢紊乱的共同机制；(2) Diann Gaalema, PhD，提高低收入患者心脏康复参与的激励机制；(3) Julie Phillips， MD，针对超重/肥胖低收入妇女妊娠期体重增加的激励措施；(4) Kim Dittus， MD, PhD，超重乳腺癌幸存者减肥成功的预测因素；(5) Brian Sprague，博士，导管原位癌患者的行为、慢性疾病和生活质量。该中心将汇集一个跨学科的团队，包括有成就的资深科学家、有前途的初级研究人员、杰出的顾问和合作者，他们将密切合作，在对美国公共卫生至关重要的临床研究领域建立一个卓越的中心。

DESCRIPTION (provided by applicant): This is a revised application for support to establish a Center for Biomedical Research Excellence (COBRE) in Behavior and Health at the University of Vermont (UVM). The proposed center will investigate relationships between personal behaviors and risk for chronic disease and premature death. Unhealthy personal behaviors (e.g., substance abuse, physical inactivity) account for 40% of premature deaths in the U.S. annually and substantially increase healthcare costs and health disparities. There is a tremendous need for (a) greater scientific understanding of the mechanisms underpinning vulnerability to these risk behaviors and (b) more effective interventions to promote behavior change. We will approach these challenges from a behavioral economics conceptual framework. This effort will involve key interdisciplinary collaborations (a) across multiple departments and colleges within UVM, (b) with key Vermont community healthcare leaders, and (c) with other universities, including two from IDeA states (Brown University and University of Kentucky). Specific Aims of this proposal are: Aim 1: Establish the cores necessary to develop and sustain a vibrant interdisciplinary center of research excellence. Goals of this aim include developing (a) an Administrative Core that provides leadership, organizational structure, intellectual infrastructure, a mentoring plan, fiscal management, and strategic planning for fiscal support beyond COBRE funding; (b) a Behavioral Economics and Intervention Sciences Core that supports intervention development and evaluation, econometric modeling of cost effectiveness, and the study of health-related decision making and its neurobiological underpinnings, and (c) a Collaboration, Dissemination, and Education Core to facilitate those key missions. Aim 2: Support the selection and career development of excellent junior\faculty Project Directors (PDs) who will become the nucleus of the center. The PDs and their research topics are: (1) Robert Althoff, MD, PhD, Shared Mechanisms in Child Dysregulation, Adult Psychopathology, and Metabolic Disorders; (2) Diann Gaalema, PhD, Incentives to Improve Cardiac Rehabilitation Participation in Low-income Patients; (3) Julie Phillips, MD, Incentives Targeting Gestational Weight Gain in Overweight/Obese Low-income Women; (4) Kim Dittus, MD, PhD, Predictors of Weight Loss Success in Overweight Breast Cancer Survivors; (5) Brian Sprague, PhD, Behaviors, Chronic Disease, and Quality of Life After Ductal Carcinoma In Situ. The proposed center will bring together an interdisciplinary group of accomplished senior scientists, promising junior investigators, and distinguished advisors and collaborators to work closely together to establish a center of excellence in an area of clinical research that is vitall important to the U.S. public health.