Sleep Medicine Neurobiology and Epidemiology

 描述(由申请者提供)：这项培训资助培养睡眠健康及其生理学领域的医生和博士后研究人员，以及睡眠障碍的流行病学和治疗，睡眠障碍对个人生活质量产生重大影响，并在我们的社会产生导致行为和心血管疾病的疾病。在许多层面的转化性研究中，都需要基础发现和临床结果研究。传统上，因果路径被认为与肥胖、性别、衰老等有关，并通过生理测试进行临床评估。因此，睡眠医学(睡眠生理学和昼夜节律)在生物标志物、蛋白质网络和脑生理学的功能理解方面仍然存在重大差距，这将为未来的治疗和预防提供信息。其中一个障碍是缺乏翻译领域的研究人员，以及受训人员看到更广泛图景的能力--即临床医生认识到基本的 了解临床疾病或证候的研究和基础研究人员。显然有机会通过比较有效性研究或新技术来改进目前的治疗方法。该项目由凯斯西储大学睡眠障碍研究中心主任金曼·P·斯特罗尔指导。该中心现在进入了大学的三个学院(医学、工程和护理)，并雇用了四个克利夫兰学术医学中心。他和他的两名副主任批准该项目的录取，并使用形成性的综合评估工具监控学员的进步。回顾和展望，该计划将朝着流行病学和生理学的根基迈进，但仍将保留系统生物学和生物信息学以及临床调查的课程元素和硕士学位。核心是由12名教师导师和4名职业早期教师组成的“初级培训师”；以及9名经验丰富的睡眠教师，他们同意作为实习生委员会的成员参加。名单上的教师代表六个系，每个系都发表了睡眠、昼夜生物学、睡眠流行病学、呼吸控制和/或临床调查方面的工作。该项目要求两名研究生和两名博士后实习生。我们为医学博士后实习生提供临床调查(CTST临床研究学者计划)或系统生物学硕士学位的选择。对于所有受训者来说，本质是个性化的、有监督的研究培训；所有受训者都会参加包括睡眠科学和医学、接触其伦理、法律和社区问题以及职业发展在内的教学工作。对于博士前实习生，学位授予部门决定课程工作、论文进度和毕业状态，至少有一名T32教职员工是博士委员会的成员。博士后实习生还创建了一个培训委员会，评估他们的进步，并提供职业指导。所有受训人员都有一系列工作，并对进展情况进行自我评估，这是半年度评估的基础。所有学员都需要参加睡眠大轮回和诊所，以及小组与外部顾问和教职员工的年度务虚会。一个很强的特点是医学、儿科学、生理学和生物物理学、神经科学、计算机科学和工程学以及生物统计学和流行病学之间的跨学科联系。该提案针对的是研究人员需要更好地管理睡眠问题和障碍，如睡眠呼吸暂停和失眠，这些问题和障碍对美国和世界的公共健康都有重大影响。这些方法包括一个结构化的项目，在这个项目中，研究生、内科科学家和博士后研究员学习计划、进行和发表关于睡眠、睡眠障碍及其与人类疾病的关系的研究。(摘要结束)

 DESCRIPTION (provided by applicant): This training grant produces physician and post-doctoral investigators in the field of sleep health and its physiology and the epidemiology and treatment of sleep disorders that substantially impact individual quality-of-life and produce illnesses causing behavioral and cardiovascular morbidity in our society. There are needs for basic discovery and clinical outcomes research at many levels of translational research. Causal pathways are traditionally considered in the associations with obesity, gender, aging, etc., and clinical assessments though physiologic testing. As a result, science of sleep medicine (sleep physiology and circadian rhythm) still has major gaps in functional understanding of biologic markers, protein networks, and brain physiology which will inform future treatments and prevention. There One barrier is a paucity of investigators across the translational spectrum and the ability of trainees to see the broader picture- i.e. clinicians appreciating the need for basic research and those in fundamental research understanding the clinical disease or syndrome. There are evident opportunities to improve current therapy through comparison effectiveness studies or new technology. The program is directed by Kingman P. Strohl, who heads the Center for Sleep Disorders Research at Case Western Reserve University. This Center now reaches into three Schools in the University (Medicine, Engineering, and Nursing) and engages four Cleveland academic medical centers. He and his two Associate Directors approve admission to the program and monitor trainees' progress using formative, comprehensive assessment tools. Looking backwards and forwards, the program will move towards its roots in epidemiology and physiology, yet retain curricular element and M.S. degrees in Systems Biology and Bioinformatics, and Clinical Investigation. There is a core of twelve faculty mentors and four early career faculty as "junior trainers"; and nine experienced sleep faculty who agree to participate as a member of a trainee committee. Listed faculty represent six departments and each has published work in sleep, circadian biology, sleep epidemiology, respiratory control, and/or clinical investigation. The program requests two post-graduate, and two pre-doctoral trainees. We provide options for a Master's Degree in Clinical Investigation (the CTST Clinical Research Scholars Program) or in Systems Biology for MD post-doctoral trainees. For all trainees the essence is individualized, supervised research training; and all trainees meet to engage in didactic work encompassing sleep science and medicine, exposure to its ethical, legal, and community issues, and career development. For pre-doctoral trainees, the degree-granting department determines course work, thesis progress and graduation status, with at least one T32 faculty as a member of the Ph.D. committee. Post-doctoral trainees also create a training committee which assesses their progress, and provides career guidance. All trainees maintain a portfolio of work with self-assessments of progress that forms the basis for semi-annual assessments. Attendance at Sleep Grand Rounds and in the clinic is required for all mentees, and as is the annual retreat of the group with outside advisors and faculty. A strong feature is the interdisciplinary linkages among Medicine, Pediatrics, Physiology & Biophysics, Neuroscience, Computer Sciences and Engineering, and Biostatistics and Epidemiology. The proposal addresses the need for researchers to better manage sleep problems and disorders, like sleep apnea and insomnia, which significantly affect public health in the United States and the world. The methods involve a structured program in which graduate students, physician- scientists, and postdoctoral PhD fellows learn to plan, conduct, and publish research in sleep, its disorders, and its relationship to human illness. (End of Abstract)