Postdoctoral Training in the Biology of Drug Abuse

摘要 这项培训补助金的总体目的是为年轻的基础研究人员提供博士后培训。 药物滥用神经生物学领域的科学家和医生，重点是 精神兴奋剂和阿片类药物在遗传、分子、电路和 行为水平。我们的目标是提供一个令人兴奋的和创新的环境与世界 一流的设施和教师，以培养下一代的科学家在药物滥用工作。 培训将在密歇根大学的多学科环境中进行。学院 成员都是NIDA的受资助者（或共同研究者），并具有神经生物学方面的专业知识， 药物滥用，特别侧重于阿片类药物和精神兴奋剂药物领域。 该提案的重点是对博士后研究员进行最先进方法的培训， 研究精神药物滥用的潜在机制。这包括研究 导致易受药物滥用影响的遗传、发育和环境因素; 滥用药物在分子、细胞、解剖和行为上的作用方式 水平;以及精神活性药物对大脑的长期影响， 通过神经可塑性的机制;以及药物的开发， 战略布局工作假设是，功能和结构性脑重塑 与慢性药物使用相关的基础是耐受性、致敏性、身体 对这些药物的依赖和心理成瘾。药物滥用研究界 在密歇根大学的高质量，并在该领域有着悠久的历史。超出了他们 个人的优势，培训教师有长期的协作科学和 训练彼此之间的关系。这些历史优势最近得到了进一步加强 密歇根大学的一系列举措加强了这一点，旨在促进生活 一般的科学研究，特别是神经科学研究。其中包括国家- 用于小鼠和大鼠遗传学、基因组学、蛋白质组学和信息学的艺术工具。所以我们 博士后研究员将受益于一个高度复杂的，但支持，研究和培训 环境

Abstract The overall purpose of this training grant is to provide postdoctoral training to young basic scientists and physicians in the area of neurobiology of substance abuse, with a focus on the mode of action of psychostimulant and opiate drugs at the genetic, molecular, circuit and behavioral levels. Our objective is to provide an exciting and innovative environment with world class facilities and faculty to develop the next generation of scientists working in drug abuse. Training will take place in the multidisciplinary setting at the University of Michigan. The faculty members are all NIDA grantees (or co-Investigators) and have expertise in the neurobiology of substance abuse, with particular emphasis on the area of opioid and psychostimulant drugs. The focus of the proposal is the training of postdoctoral fellows in state-of-the-art approaches for studying mechanisms underlying abuse of psychoactive drugs. This includes studying the genetic, developmental and environmental factors that lead to vulnerability to substance abuse; the mode of action of drugs of abuse at the molecular, cellular, anatomical and behavioral levels; and the long-term consequences of psychoactive drugs on the brain, as mediated through mechanisms of neural plasticity; and the development of medications, and prevention strategies. The working assumption is that the functional and structural brain remodeling associated with chronic drug use lies at the basis of tolerance, sensitization, physical dependence, and psychological addiction to these drugs. The drug abuse research community at the University of Michigan is of high quality and has a long history in the field. Beyond their individual strengths, the training faculty members have long-standing collaborative scientific and training relationships with each other. These historical strengths have recently been further enhanced with a number of initiatives at the University of Michigan, designed to facilitate life science research in general, and neuroscience research in particular. They include state-of-the- art tools for mouse and rat genetics, genomics, proteomics, and informatics. Thus, our postdoctoral fellows will profit from a highly sophisticated, yet supportive, research and training environment.