Improved long-term biocompatibility of coronary stents by plasma coating process

等离子涂层技术改善冠状动脉支架长期生物相容性的研究 摘要 药物洗脱支架(DES)已广泛应用于冠心病患者的治疗 由于其比裸金属支架(BMS)更好地控制再狭窄的能力。然而，有一个很高的 患者植入DES后晚期支架内血栓形成的风险，这可能导致 致命的心脏病发作和死亡，尽管发生率很低。因此，为了安全有效地临床使用， 冠状动脉支架需要在其表面具有更好的长期生物相容性，以提供 除了抑制血管细胞增殖从而减缓速度外，还具有足够的抗血栓作用 支架周围的组织向下愈合。Nanova，Inc.正在开发一种高性能的新型涂层 不锈钢或铬钴支架表面的抗血栓性能。一种环保的 良性技术，低温等离子体工艺是用来沉积超薄(纳米级)但 连续的涂层，足以产生所需的耐磨性并固定 在随后的表面处理中产生的生物活性官能团，以防止血液凝结和 再狭窄，但足够薄，当支架进入支架时，支架可以扩张而不会破裂 患者的冠状动脉粥样硬化。在这个创新的研究项目中获得的知识 也将有利于研究和开发，以改善其他植入性医疗的生物兼容性 起搏器、脉冲发生器、心脏除颤器和生物传感器等设备。

Improved long-term biocompatibility of coronary stents by plasma coating process Abstract Drug-eluting stents (DES) have been widely used to treat patients of coronary heart disease (CHD) due to their better ability to control restenosis than bare metal stents (BMS). However, there is a high risk of late in-stent thrombosis associated with DES after implantation in patients, which could lead to fatal heart attack and death even though it occurs at low rate. Thus, for safe and effective clinical use, a coronary stent needs to have better long-term biocompatibility on its surface that will provide sufficient thrombo-resistance in addition to inhibiting smooth muscle cell proliferation thereby slowing down healing of tissues around the stent. Nanova, Inc. is developing a novel coating layer of high thrombo-resistance on the surface of stents made of stainless steel or CrCo. An environmentally benign technology, low temperature plasma process is used to deposit an ultra-thin (nano-scale) but continuous layer of coating, sufficient to generate desired abrasion resistance and immobilize the bioactive functional groups created in the subsequent surface treatment to prevent blood clotting and restenosis, but thin enough to allow for stent expansion without cracking when delivered into the atherosclerotic coronary arteries of patients. The knowledge gained in this innovative research project will also benefit research and development for improved biocompatibility for other implantable medical devices such as pacemakers, pulse generators, cardiac defibrillators and bio-sensors.