Gene Wiki: expanding the ecosystem of community-intelligence resources

描述(由申请人提供)：本提案描述了基因维基的持续维护和发展，其目标是为每个人类基因创建一篇持续更新、社区审查和合作撰写的评论文章。基因维基是直接在维基百科中创建的，它是由10,646篇特定基因文章组成的非正式集合。在第一个资助期，开发了使基因维基“信息箱”与基因组学社区的源数据库保持同步的基础设施。接下来，评估和量化基因维基文章中每个词的可信度的方法被开发出来，并在一个名为WikiTrust的系统中实现。最后，将简单的文本挖掘应用于基因维基，能够识别数千种新的基因注释。在接下来的项目期间，吉恩维基做好了进一步发展的准备。首先，基因维基的范围将扩大到也包括关于疾病和药物的评论文章。将通过这一倡议创建或维护数千篇文章，特别强调罕见疾病。第二，专门的外联部分将确保编辑群体不断壮大。这项外展工作将吸引对感兴趣的特定基因方面的专家的教职员工，以及希望为课堂项目设计基于基因维基的课程的各级课堂讲师。第三，将在维基数据环境中建立一个“中央模式生物数据库”，作为微生物基因和基因组注释数据的交换中心。第四，将创建一个全新的众包应用程序，利用与患者结盟的人群以及他们推进研究的愿望。这些人将是一个新的群体，将被应用于系统地注释生物医学文献的挑战。总之，基因维基对于生物医学研究来说是一个有用的工具。这项提议的成功完成将导致通过众包进行更有效的知识管理和传播。

DESCRIPTION (provided by applicant): This proposal describes the continued maintenance and development of the Gene Wiki, the goal of which is to create a continuously-updated, community-reviewed, and collaboratively-written review article for every human gene. The Gene Wiki was created directly within Wikipedia as an informal collection of 10,646 gene-specific articles. In the first funding period, the infrastructure to keep Gene Wiki "infoboxes" in sync wit the source databases in the genomics community was developed. Next, methods to assess and quantify the trustworthiness of each word of a Gene Wiki article were developed and implemented in a system called WikiTrust. And finally, simple text-mining applied to Gene Wiki was able to identify thousands of novel gene annotations. During the next project period, the Gene Wiki is poised to make further strides. First, the scope of the Gene Wiki will be expanded to also include review articles on diseases and drugs. Thousands of articles will either be created or maintained through this initiative with a particular emphasis on rare diseases. Second, a dedicated outreach component will ensure that the community of editors is poised to grow. This outreach effort will engage both faculty members who are experts on specific genes of interest, as well as classroom instructors at all levels who want to design curriculum based on the Gene Wiki for a class project. Third, a "Centralized Model Organism Database" will be constructed in the Wikidata environment, which will serve as a clearing house of microbial gene and genome annotation data. And fourth an entirely new crowdsourcing application will be created that taps into crowds of patient-aligned individuals and their desire to advance research. These individuals will be a novel crowd that will be applied to the challenge of systematically annotating the biomedical literature. In summary, the Gene Wiki is a useful tool for biomedical research. Successful completion of this proposal will result in more efficient knowledge management and dissemination through crowdsourcing.